De novo protein design holds promise for creating small stable proteins with shapes customized
to bind therapeutic targets. We describe a massively parallel approach for designing, …

Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks
generally have shapes that have evolved to fit precisely into binding pockets on their targets. …

Recurrent Pseudomonas aeruginosa infections coupled with robust, damaging neutrophilic
inflammation characterize the chronic lung disease cystic fibrosis (CF). The proresolving …

Small ubiquitin-like modifier (SUMO) is commonly used as a protein fusion domain to facilitate
expression and purification of recombinant proteins, and a SUMO-specific protease is …

Peptides folded through interwoven disulfides display extreme biochemical properties and
unique medicinal potential. However, their exploitation has been hampered by the limited …

Despite SARS-CoV-2 being a "novel" virus, early detection of anti-spike IgG in severe
COVID-19 patients may be caused by the amplification of humoral memory responses against …

Each year vast international resources are wasted on irreproducible research. The scientific
community has been slow to adopt standard software engineering practices, despite the …

The early modern western Indian Ocean constituted a dynamic space of human interaction.
While scholarship has mostly concentrated on trade and commerce, recent studies have …

Designing optimized proteins is important for a range of practical applications. Protein design
is a rapidly developing field that would benefit from approaches that enable many changes …

Cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is a
virulence factor secreted by Pseudomonas aeruginosa that reduces the quantity of CFTR in the …