Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double
negative; DN). We show that DN cell expansions reflected a subset of CXCR5 - CD11c + …

Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic
choriomeningitis virus infection 1 . Here we examine the underlying basis for this synergy…

Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most
common cause of cancer-related mortality in western men. To investigate the mechanisms …

SOX4 is a critical developmental transcription factor in vertebrates and is required for precise
differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in …

The differentiation of CD8 T cells in response to acute infection results in the acquisition of
hallmark phenotypic effector functions; however, the epigenetic mechanisms that program this …

An optimal gut microbiota influences many beneficial processes in the metazoan host.
However, the molecular mechanisms that mediate and function in symbiont-induced host …

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular
pathogenic B cells derived from newly activated naive cells. Although these cells express …

Programmed cell death-1 (PD-1) is responsible for T cell exhaustion during chronic viral
infections and is expressed on a variety of immune cells following activation. Despite its …

The epigenetic processes that regulate antibody-secreting plasma cells are not well understood.
Here, analysis of plasma cell differentiation revealed DNA hypomethylation of 10% of …

10.7554/eLife.41641.001 Although B cells expressing the IFNγR or the IFNγ-inducible
transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone …