Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with
cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it establishes …

Background. Cystic fibrosis (CF) lung disease is associated with diverse bacteria chronically
infecting the airways. Slow-growing, antibiotic-resistant mutants of Staphylococcus aureus …

Metagenomic sequencing is a promising approach for identifying and characterizing organisms
and their functional characteristics in complex, polymicrobial infections, such as airway …

Rationale: Pseudomonas aeruginosa undergoes phenotypic changes during cystic fibrosis (CF)
lung infection. Although mucoidy is traditionally associated with transition to chronic …

The human gastrointestinal tract consists of a dense and diverse microbial community, the
composition of which is intimately linked to health. Extrinsic factors such as diet and host …

Cystic fibrosis (CF) results in inflammation, malabsorption of fats and other nutrients, and
obstruction in the gastrointestinal (GI) tract, yet the mechanisms linking these disease …

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal
inflammation. We show that the abundances of Escherichia coli in fecal microbiota were …

Most infants with cystic fibrosis (CF) have pancreatic exocrine insufficiency that results in
nutrient malabsorption and requires oral pancreatic enzyme replacement. Newborn screening …

Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy
controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (…

We measured in vitro phenotypes of early Pseudomonas aeruginosa isolates from children
with cystic fibrosis in an antibiotic eradication therapy trial. Isolates frequently exhibited …