Development of solitary chemosensory cells in the distal lung after severe influenza injury
CK Rane, SR Jackson, CF Pastore… - … of Physiology-Lung …, 2019 - journals.physiology.org
H1N1 influenza virus infection induces dramatic and permanent alveolar remodeling mediated
by p63 + progenitor cell expansion in both mice and some patients with acute respiratory …
by p63 + progenitor cell expansion in both mice and some patients with acute respiratory …
[HTML][HTML] The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation
…, AA Dar, Y Chen, A Suresh, CF Pastore… - Nature …, 2022 - nature.com
Antigen encounter directs CD4 + T cells to differentiate into T helper or regulatory cells. This
process focuses the immune response on the invading pathogen and limits tissue damage. …
process focuses the immune response on the invading pathogen and limits tissue damage. …
[HTML][HTML] Myeloid-derived IL-33 limits the severity of dextran sulfate sodium–induced colitis
LY Hung, CF Pastore, B Douglas… - The American Journal of …, 2021 - Elsevier
IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate
inflammation. Whether IL-33 serves a pathogenic or protective role during inflammatory bowel …
inflammation. Whether IL-33 serves a pathogenic or protective role during inflammatory bowel …
Cell-intrinsic Wnt4 influences conventional dendritic cell fate determination to suppress type 2 immunity
…, Y Ji, DA Christian, KR Herbine, CF Pastore… - The Journal of …, 2019 - journals.aai.org
Whether conventional dendritic cells (cDC) acquire subset identity under direction of Wnt
family glycoproteins is unknown. We demonstrate that Wnt4, a β-catenin–independent Wnt …
family glycoproteins is unknown. We demonstrate that Wnt4, a β-catenin–independent Wnt …
[HTML][HTML] Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host
Helminth infections, including hookworms and Schistosomes, can cause severe disability
and death. Infection management and control would benefit from identification of biomarkers …
and death. Infection management and control would benefit from identification of biomarkers …
[HTML][HTML] MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity
…, LY Hung, AA Ferguson, Q Wu, CF Pastore… - Research …, 2023 - ncbi.nlm.nih.gov
Skin employs interdependent cellular networks to facilitate barrier integrity and host
immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing …
immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing …
Neuron-dependent tuft cell expansion initiates sinonasal allergic Type 2 inflammation
…, JM Inclan-Rico, MB Weiner, CF Pastore… - bioRxiv, 2023 - biorxiv.org
It is unknown whether interactions between tuft cells and trigeminal sinonasal neurons
contribute to allergic disease. Intranasal administration of house dust mite or fungal allergens …
contribute to allergic disease. Intranasal administration of house dust mite or fungal allergens …
Cell-intrinsic Wnt4 controls early cDC1 commitment and suppresses development of pathogen-specific Type 2 immunity
Whether conventional dendritic cell (cDC) precursors acquire lineage-specific identity under
direction of regenerative secreted glycoproteins within bone marrow niches is entirely …
direction of regenerative secreted glycoproteins within bone marrow niches is entirely …
Interrogating mechanisms of CD8 T cell dysfunction in obese asthma
…, S Sayed, P Conrey, J Campos, CF Pastore… - The Journal of …, 2022 - journals.aai.org
Pediatric obese atopic asthma (OA) is a complex and poorly understood disease at the
intersection of two of the most common chronic inflammatory diseases of childhood. Pediatric OA …
intersection of two of the most common chronic inflammatory diseases of childhood. Pediatric OA …
Wnt4 controls early cDC1 commitment to suppress Type 2 immunity
…, Y Ji, DA Christian, KR Herbine, CF Pastore… - The Journal of …, 2019 - journals.aai.org
Whether conventional dendritic cells (cDC) acquire subset identity under direction of regenerative
glycoproteins is unknown. We demonstrate that Wnt4, a beta-catenin independent Wnt …
glycoproteins is unknown. We demonstrate that Wnt4, a beta-catenin independent Wnt …