Development of solitary chemosensory cells in the distal lung after severe influenza injury

CK Rane, SR Jackson, CF Pastore… - … of Physiology-Lung …, 2019 - journals.physiology.org
H1N1 influenza virus infection induces dramatic and permanent alveolar remodeling mediated
by p63 + progenitor cell expansion in both mice and some patients with acute respiratory …

[HTML][HTML] The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation

…, AA Dar, Y Chen, A Suresh, CF Pastore… - Nature …, 2022 - nature.com
Antigen encounter directs CD4 + T cells to differentiate into T helper or regulatory cells. This
process focuses the immune response on the invading pathogen and limits tissue damage. …

[HTML][HTML] Myeloid-derived IL-33 limits the severity of dextran sulfate sodium–induced colitis

LY Hung, CF Pastore, B Douglas… - The American Journal of …, 2021 - Elsevier
IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate
inflammation. Whether IL-33 serves a pathogenic or protective role during inflammatory bowel …

Cell-intrinsic Wnt4 influences conventional dendritic cell fate determination to suppress type 2 immunity

…, Y Ji, DA Christian, KR Herbine, CF Pastore… - The Journal of …, 2019 - journals.aai.org
Whether conventional dendritic cells (cDC) acquire subset identity under direction of Wnt
family glycoproteins is unknown. We demonstrate that Wnt4, a β-catenin–independent Wnt …

[HTML][HTML] Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host

B Adewale, JR Heintz, CF Pastore… - PLoS Neglected …, 2021 - journals.plos.org
Helminth infections, including hookworms and Schistosomes, can cause severe disability
and death. Infection management and control would benefit from identification of biomarkers …

[HTML][HTML] MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity

…, LY Hung, AA Ferguson, Q Wu, CF Pastore… - Research …, 2023 - ncbi.nlm.nih.gov
Skin employs interdependent cellular networks to facilitate barrier integrity and host
immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing …

Neuron-dependent tuft cell expansion initiates sinonasal allergic Type 2 inflammation

…, JM Inclan-Rico, MB Weiner, CF Pastore… - bioRxiv, 2023 - biorxiv.org
It is unknown whether interactions between tuft cells and trigeminal sinonasal neurons
contribute to allergic disease. Intranasal administration of house dust mite or fungal allergens …

Cell-intrinsic Wnt4 controls early cDC1 commitment and suppresses development of pathogen-specific Type 2 immunity

LY Hung, Y Ji, DA Christian, KR Herbine, CF Pastore… - bioRxiv, 2018 - biorxiv.org
Whether conventional dendritic cell (cDC) precursors acquire lineage-specific identity under
direction of regenerative secreted glycoproteins within bone marrow niches is entirely …

Interrogating mechanisms of CD8 T cell dysfunction in obese asthma

…, S Sayed, P Conrey, J Campos, CF Pastore… - The Journal of …, 2022 - journals.aai.org
Pediatric obese atopic asthma (OA) is a complex and poorly understood disease at the
intersection of two of the most common chronic inflammatory diseases of childhood. Pediatric OA …

Wnt4 controls early cDC1 commitment to suppress Type 2 immunity

…, Y Ji, DA Christian, KR Herbine, CF Pastore… - The Journal of …, 2019 - journals.aai.org
Whether conventional dendritic cells (cDC) acquire subset identity under direction of regenerative
glycoproteins is unknown. We demonstrate that Wnt4, a beta-catenin independent Wnt …