Obesity is an important cause of morbidity and mortality in developed countries, and is also
becoming increasingly prevalent in the developing world. Although environmental factors are …

Polycomb group proteins (PCGs) are involved in repression of genes that are required for
stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%,
implicating roles for genetic and non-genetic factors in the aetiology of this complex …

Recent multi-dimensional approaches to the study of complex disease have revealed powerful
insights into how genetic and epigenetic factors may underlie their aetiopathogenesis. …

Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …

Twin pairs discordant for disease may help elucidate the epigenetic mechanisms and causal
environmental factors in disease development and progression. To obtain the numbers of …

… Author links open overlay panel Yohan Davit a b , Christopher G. Bell c , Helen M. Byrne c d
… general and powerful convergence principles such as Γ - , G - or H - convergence (see eg, […

Two major mechanisms are involved in the formation of blood vasculature: vasculogenesis
and angiogenesis. The former term describes the formation of a capillary-like network from …

10.7554/eLife.31977.001 Human genetic studies have emphasised the dominant contribution
of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited …