Advances in the synthesis and screening of small-molecule libraries have accelerated the
discovery of chemical probes for studying biological processes. Still, only a small fraction of …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet, …

Synthetic immunology, the development of synthetic systems capable of modulating and/or
manipulating immunological functions, represents an emerging field of research with …

Protein acetylation is a central event in orchestrating diverse cellular processes. However,
current strategies to investigate protein acetylation in cells are often nonspecific or lack …

Haem is an essential prosthetic group of numerous proteins and a central signalling
molecule in many physiologic processes 1 , 2 . The chemical reactivity of haem means that a …

A fundamental challenge in chemical biology and medicine is to understand and expand
the fraction of the human proteome that can be targeted by small molecules. We recently …

The use of photo-affinity reagents for the mapping of noncovalent small molecule–protein
interactions has become widespread. Recently, several ‘fully-functionalized’ (FF) chemical …

HIV/AIDS is a global pandemic for which new treatment strategies are desperately needed.
We have designed a novel small molecule, designated as ARM-H, that has the potential to …

Marine-derived cyclic imine toxins, portimine A and portimine B, have attracted attention
because of their chemical structure and notable anti-cancer therapeutic potential 1 , 2 , 3 – 4 . …

RNAs have important functions that are dictated by their structure. Indeed, small molecules
that interact with RNA structures can perturb function, serving as chemical probes and lead …