Exercise training induces mitochondrial biogenesis, but the time course of molecular sequelae
that accompany repetitive training stimuli remains to be determined in human skeletal …

High-intensity aerobic interval training (HIIT) is a compromise between time-consuming
moderate-intensity training and sprint-interval training requiring all-out efforts. However, there …

The effects of training on silent mating-type information regulator 2 homolog 1 (SIRT1) activity
and protein in relationship to peroxisome proliferator-activated receptor γ coactivator-1α (…

A growing body of research is investigating the potential contribution of mitochondrial function
to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are …

Assessment of mitochondrial ADP-stimulated respiratory kinetics in PmFBs (permeabilized
fibre bundles) is increasingly used in clinical diagnostic and basic research settings. However…

Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes
severe locomotor limitations and early death due in part to respiratory muscle failure. Given …

Aims/hypothesis A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial
bioenergetics has not been undertaken in individuals with type 1 diabetes. This study …

40 SIRT1 is proposed to contribute the control of exercise mediated increases in
mitochondrial 41 biogenesis through the deacetylation, and activation, of PGC-1α. The current …

Thermogenic (beige and brown) adipocytes protect animals against obesity and metabolic
disease. However, little is known about the mechanisms that commit stem cells toward …

Key point • ATP transfer from mitochondria to the cytoplasm occurs mainly through phosphate
transfer to creatine by mitochondrial creatine kinase (miCK) but also by transport and/or …