Cerebellar modulation of the reward circuitry and social behavior
INTRODUCTION Although the cerebellum has long been considered to be a purely motor
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …
Short latency cerebellar modulation of the basal ganglia
CH Chen, R Fremont, EE Arteaga-Bracho… - Nature …, 2014 - nature.com
The graceful, purposeful motion of our body is an engineering feat that remains unparalleled
in robotic devices using advanced artificial intelligence. Much of the information required for …
in robotic devices using advanced artificial intelligence. Much of the information required for …
A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain
In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety
and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly …
and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly …
Focal radiation therapy dose escalation improves overall survival in locally advanced pancreatic cancer patients receiving induction chemotherapy and consolidative …
S Krishnan, AS Chadha, Y Suh, HC Chen… - International Journal of …, 2016 - Elsevier
Purpose To review outcomes of locally advanced pancreatic cancer (LAPC) patients treated
with dose-escalated intensity modulated radiation therapy (IMRT) with curative intent. …
with dose-escalated intensity modulated radiation therapy (IMRT) with curative intent. …
A DNA-based molecular probe for optically reporting cellular traction forces
We developed molecular tension probes (TPs) that report traction forces of adherent cells
with high spatial resolution, can in principle be linked to virtually any surface, and obviate …
with high spatial resolution, can in principle be linked to virtually any surface, and obviate …
[HTML][HTML] Lecanemab in early Alzheimer's disease
…, P Aisen, RJ Bateman, C Chen… - … England Journal of …, 2023 - Mass Medical Soc
Background The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may
initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized …
initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized …
Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context
H Chen, LM Wilkins, N Aziz, C Cannings… - Human molecular …, 2006 - academic.oup.com
We questioned the significance of haplotype structure in gene regulation by testing whether
individual single nucleotide polymorphisms (SNPs) within a gene promoter region […
individual single nucleotide polymorphisms (SNPs) within a gene promoter region […
[HTML][HTML] Solar wind turbulence and the role of ion instabilities
Solar wind is probably the best laboratory to study turbulence in astrophysical plasmas. In
addition to the presence of magnetic field, the differences with neutral fluid isotropic …
addition to the presence of magnetic field, the differences with neutral fluid isotropic …
Noradrenergic changes, aggressive behavior, and cognition in patients with dementia
KL Matthews, CPLH Chen, MM Esiri, J Keene… - Biological …, 2002 - Elsevier
Background: We wished to examine the integrity of the noradrenergic system in patients
with Alzheimer’s disease, mixed/other dementias and controls, and possible relationships …
with Alzheimer’s disease, mixed/other dementias and controls, and possible relationships …
Progression of cognitive impairment after stroke: one year results from a longitudinal study of Singaporean stroke patients
…, ML Goh, HM Chang, MC Wong, CPLH Chen - Journal of the …, 2002 - Elsevier
Background and purpose: Vascular dementia accounts for 40–50% of dementia cases in
Singapore. The aim of this study is to examine the prevalence and natural history of cognitive …
Singapore. The aim of this study is to examine the prevalence and natural history of cognitive …