User profiles for Christopher H. Chen

Christopher HK Chen

- Verified email at qmul.ac.uk - Cited by 6720

Christopher H Chen

- Verified email at psu.edu - Cited by 1380

Cerebellar modulation of the reward circuitry and social behavior

I Carta, CH Chen, AL Schott, S Dorizan, K Khodakhah - Science, 2019 - science.org
INTRODUCTION Although the cerebellum has long been considered to be a purely motor
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …

Short latency cerebellar modulation of the basal ganglia

CH Chen, R Fremont, EE Arteaga-Bracho… - Nature …, 2014 - nature.com
The graceful, purposeful motion of our body is an engineering feat that remains unparalleled
in robotic devices using advanced artificial intelligence. Much of the information required for …

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain

CH Chen, LN Newman, AP Stark, KE Bond… - Nature …, 2023 - nature.com
In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety
and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly …

Focal radiation therapy dose escalation improves overall survival in locally advanced pancreatic cancer patients receiving induction chemotherapy and consolidative …

S Krishnan, AS Chadha, Y Suh, HC Chen… - International Journal of …, 2016 - Elsevier
Purpose To review outcomes of locally advanced pancreatic cancer (LAPC) patients treated
with dose-escalated intensity modulated radiation therapy (IMRT) with curative intent. …

A DNA-based molecular probe for optically reporting cellular traction forces

…, BM Baker, SM Block, DR Liu, CS Chen - Nature …, 2014 - nature.com
We developed molecular tension probes (TPs) that report traction forces of adherent cells
with high spatial resolution, can in principle be linked to virtually any surface, and obviate …

[HTML][HTML] Lecanemab in early Alzheimer's disease

…, P Aisen, RJ Bateman, C Chen… - … England Journal of …, 2023 - Mass Medical Soc
Background The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may
initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized …

Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context

H Chen, LM Wilkins, N Aziz, C Cannings… - Human molecular …, 2006 - academic.oup.com
We questioned the significance of haplotype structure in gene regulation by testing whether
individual single nucleotide polymorphisms (SNPs) within a gene promoter region […

[HTML][HTML] Solar wind turbulence and the role of ion instabilities

O Alexandrova, CHK Chen, L Sorriso-Valvo… - Space Science …, 2013 - Springer
Solar wind is probably the best laboratory to study turbulence in astrophysical plasmas. In
addition to the presence of magnetic field, the differences with neutral fluid isotropic …

Noradrenergic changes, aggressive behavior, and cognition in patients with dementia

KL Matthews, CPLH Chen, MM Esiri, J Keene… - Biological …, 2002 - Elsevier
Background: We wished to examine the integrity of the noradrenergic system in patients
with Alzheimer’s disease, mixed/other dementias and controls, and possible relationships …

Progression of cognitive impairment after stroke: one year results from a longitudinal study of Singaporean stroke patients

…, ML Goh, HM Chang, MC Wong, CPLH Chen - Journal of the …, 2002 - Elsevier
Background and purpose: Vascular dementia accounts for 40–50% of dementia cases in
Singapore. The aim of this study is to examine the prevalence and natural history of cognitive …