This review will provide an in-depth discussion on the previous development of nanoparticle-based
drug delivery systems (DDS) and discuss original research data that includes the …

Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease,
can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated …

Complex dosing regimens, costs, side effects, biodistribution limitations, and variable drug
pharmacokinetic patterns have affected the long-term efficacy of antiretroviral medicines. To …

Antiretroviral therapy (ART) shows variable blood-brain barrier penetration. This may affect
the development of neurological complications of HIV infection. In attempts to attenuate viral …

Objective Infective endocarditis is associated with high morbidity and mortality and optimal
timing for surgical intervention is unclear. We performed a systematic review and meta-…

Background Combination antiretroviral (AR) therapy continues to be the mainstay for HIV
treatment. However, antiretroviral drug nonadherence can lead to the development of …

The objective of this investigation was to develop a thermosensitive vaginal gel containing
raltegravir+efavirenz loaded PLGA nanoparticles (RAL+EFV–NPs) for pre-exposure …

Study Objective. To examine the impact of individualized pharmacokinetic monitoring (IPM)
on the development of aminoglycoside‐associated nephrotoxicity (AAN). Design. …

Background: Human immunodeficiency virus type-1 (HIV-1) infection leads to acquired
immunodeficiency syndrome (AIDS), a severe viral infection that has claimed approximately …

Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century.
More than 33 million individuals are infected with HIV worldwide and more than 2 million …