User profiles for Christopher J Philp
Christopher J PhilpSir Peter Mansfield Imaging Centre, University of Nottingham Verified email at nottingham.ac.uk Cited by 322 |
Extracellular matrix cross-linking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis
… Correspondence and requests for reprints should be addressed to Christopher J. Philp,
Ph.D., Division of Respiratory Medicine, School of Medicine, Queens Medical Centre, University …
Ph.D., Division of Respiratory Medicine, School of Medicine, Queens Medical Centre, University …
Matrix-bound growth factors are released upon cartilage compression by an aggrecan-dependent sodium flux that is lost in osteoarthritis
Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic
mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair …
mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair …
[HTML][HTML] Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus
P Hanson, CJ Philp, HS Randeva, S James… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND. Dietary sodium intake mismatches urinary sodium excretion over prolonged
periods. Our aims were to localize and quantify electrostatically bound sodium within …
periods. Our aims were to localize and quantify electrostatically bound sodium within …
[HTML][HTML] A theoretical model of inflammation-and mechanotransduction-driven asthmatic airway remodelling
Inflammation, airway hyper-responsiveness and airway remodelling are well-established
hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better …
hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better …
Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis
Airway remodeling occurs in chronic asthma leading to increased airway smooth muscle (ASM)
mass and extracellular matrix (ECM) deposition. Although extensively studied in murine …
mass and extracellular matrix (ECM) deposition. Although extensively studied in murine …
[HTML][HTML] Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement
…, JL Krupa, AJ Taylor, F Zamberlan, CJ Philp… - Contrast Media & …, 2019 - hindawi.com
Paramagnetic gadolinium ions (Gd III ), complexed within DOTA-based chelates, have
become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of …
become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of …
[HTML][HTML] Growth factor release upon cartilage injury is due to aggrecan-dependent sodium flux that is lost in osteoarthritis
Purpose: Growth factors sequestered in the pericellular matrix (PCM) of cartilage are released
upon tissue injury and are thought to confer largely chondroprotective effects in vivo. Of …
upon tissue injury and are thought to confer largely chondroprotective effects in vivo. Of …
The potential therapeutic effect of manipulating the extracellular matrix in idiopathic pulmonary fibrosis
CJ Philp - 2016 - eprints.nottingham.ac.uk
Background: Idiopathic Pulmonary Fibrosis (IPF) is a physiologically devastating disease.
The debilitating nature and high mortality rates make this one of the most lethal conditions, …
The debilitating nature and high mortality rates make this one of the most lethal conditions, …
ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis
CJ Philp, I Siebeke, D Clements… - American Journal … - nottingham-repository.worktribe.com
Idiopathic pulmonary fibrosis (IPF) is characterised by accumulation of extra cellular matrix (ECM)
proteins and fibroblast proliferation. ECM cross-linking enzymes have been implicated …
proteins and fibroblast proliferation. ECM cross-linking enzymes have been implicated …
[PDF][PDF] Supplementary Materials for: Accelerated 19F MRI detection of matrix metalloproteinase-2/-9 through responsive deactivation of paramagnetic relaxation …
HM Faas, JL Krupa, AJ Taylor, F Zamberlan, CJ Philp… - downloads.hindawi.com
The synthesis began with 3, 5-bis (trifluoromethyl) benzylamine (2), an inexpensive reagent
which provided six magnetically and chemically equivalent fluorine atoms. This benzyl …
which provided six magnetically and chemically equivalent fluorine atoms. This benzyl …