Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic
lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to …

Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new
opportunities for drug development. The apicoplast – although no longer photosynthetic – is …

Transit peptides mediate protein targeting into plastids and are only poorly understood. We
extracted amino acid features from transit peptides that target proteins to the relict plastid (…

The apicoplast and mitochondrion of the malaria parasite Plasmodium falciparum are
important intracellular organelles and targets of several anti-malarial drugs. In recent years, our …

The malaria parasite, Plasmodium falciparum, exploits multiple ligand-receptor interactions,
called invasion pathways, to invade the host erythrocyte. Strains of P. falciparum vary in their …

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as access to …

Plasmodium parasites are unicellular eukaryotes that undergo a series of remarkable
morphological transformations during the course of a multistage life cycle spanning two hosts (…

Cytoadherance of Plasmodium falciparum -infected erythrocytes in the brain, organs and
peripheral microvasculature is linked to morbidity and mortality associated with severe malaria. …

The basic organisation of the endomembrane system is conserved in all eukaryotes and
comparative genome analyses provides compelling evidence that the endomembrane system …

The phylum Apicomplexa comprises a group of obligate intracellular parasites of broad
medical and agricultural significance, including Toxoplasma gondii and the malaria-causing …