Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue-…

Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells can be achieved
by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority …

Pluripotent cells can be derived from fibroblasts by ectopic expression of defined transcription
factors. A fundamental unresolved question is whether terminally differentiated cells can …

Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos
but have very different biological properties, and molecular analyses suggest that the …

Pluripotency can be induced in differentiated murine and human cells by retroviral transduction
of Oct4, Sox2, Klf4, and c-Myc. We have devised a reprogramming strategy in which …

The study of induced pluripotency is complicated by the need for infection with high-titer
retroviral vectors, which results in genetically heterogeneous cell populations. We generated …

We present an overview of the concepts of tissue-specific transcriptional control mechanisms
essential for development of the bone cell phenotype. BMP2 induced transcription factors …

The Pou domain containing transcription factor Oct4 is a well-established regulator of pluripotency
in the inner cell mass of the mammalian blastocyst as well as in embryonic stem cells. …

Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for
its prevention and therapy are urgently needed 1 . Here we identify a metabolite signalling …

The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of
pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs (hESCs) invariably …