[HTML][HTML] Cathepsin S: therapeutic, diagnostic, and prognostic potential
RDA Wilkinson, R Williams, CJ Scott… - Biological chemistry, 2015 - degruyter.com
Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal
protease which can promote degradation of damaged or unwanted proteins in the endo-lysosomal …
protease which can promote degradation of damaged or unwanted proteins in the endo-lysosomal …
Antibody-targeted nanoparticles for cancer therapy
F Fay, CJ Scott - Immunotherapy, 2011 - Future Medicine
In recent years, nanoparticulate-mediated drug delivery research has examined a full spectrum
of nanoparticles that can be used in diagnostic and therapeutic cancer applications. A …
of nanoparticles that can be used in diagnostic and therapeutic cancer applications. A …
[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-a treasure trove of untapped clinical potential
…, J Sasiwachirangkul, R Williams, CJ Scott - Molecular Aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression profile, …
particular interest due to distinctive properties including a normal restricted expression profile, …
Human apolipoprotein AI gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.
AS Plump, CJ Scott, JL Breslow - Proceedings of the …, 1994 - National Acad Sciences
Atherosclerosis is a complex disease with both genetic and environmental determinants.
Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to …
Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to …
Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
…, K Migalska, E Ryan, D Gillen, CJ Scott… - Pharmaceutical …, 2011 - Springer
Purpose Design and evaluation of a novel laser-based method for micromoulding of microneedle
arrays from polymeric materials under ambient conditions. The aim of this study was to …
arrays from polymeric materials under ambient conditions. The aim of this study was to …
Visible Virchow-Robin spaces on magnetic resonance imaging of Alzheimer's disease patients and normal elderly from the Sunnybrook Dementia Study
Background: Visible Virchow-Robin spaces (VRS) are commonly used markers for small
vessel disease in aging and dementia. Objective: However, as previous reports were based on …
vessel disease in aging and dementia. Objective: However, as previous reports were based on …
Lesion Explorer: a comprehensive segmentation and parcellation package to obtain regional volumetrics for subcortical hyperintensities and intracranial tissue
Subcortical hyperintensities (SH) are a commonly observed phenomenon on MRI of the
aging brain (Kertesz et al., 1988). Conflicting behavioral, cognitive and pathological …
aging brain (Kertesz et al., 1988). Conflicting behavioral, cognitive and pathological …
Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection
…, RF Donnelly, CC Taggart, CJ Scott - International journal …, 2012 - Taylor & Francis
Gentamicin is an aminoglycoside antibiotic commonly used for treating Pseudomonas
infections, but its use is limited by a relatively short half-life. In this investigation, developed a …
infections, but its use is limited by a relatively short half-life. In this investigation, developed a …
[HTML][HTML] Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments
…, K Campbell, P Smyth, M Fernández, CJ Scott… - Chemical …, 2018 - pubs.rsc.org
The successful development of targeted nanotherapeutics is contingent upon the conjugation
of therapeutic nanoparticles to target-specific ligands, with particular emphasis being …
of therapeutic nanoparticles to target-specific ligands, with particular emphasis being …
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
SJ Orr, NM Morgan, J Elliott, JF Burrows, CJ Scott… - Blood, 2007 - ashpublications.org
CD33 is a member of the sialic acid–binding immunoglobulin-like lectin (Siglec) family of
inhibitory receptors and a therapeutic target for acute myeloid leukemia (AML). CD33 contains …
inhibitory receptors and a therapeutic target for acute myeloid leukemia (AML). CD33 contains …