User profiles for Christopher J. Ormandy
 | CJ OrmandyOther name: Christopher J Ormandy Founder and Director MammBio Pty Ltd and Visiting Scientist Garvan Institute of Medical … Verified email at garvan.org.au Cited by 12063 |
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.
Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced
by gene targeting in embryonic stem cells. Heterozygous females showed almost complete …
by gene targeting in embryonic stem cells. Heterozygous females showed almost complete …
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
Breast cancer is one of the most common cancers in humans and will on average affect up
to one in eight women in their lifetime in the United States and Europe 1 . The Women’s …
to one in eight women in their lifetime in the United States and Europe 1 . The Women’s …
Prolactin controls mammary gland development via direct and indirect mechanisms
…, RA Weinberg, PA Kelly, CJ Ormandy - Developmental …, 1999 - Elsevier
… The PRLR-deficient mice were generated by replacement of exon 5 (Ormandy, 1998), … with
the NEO cassette (Ormandy, 1997a). Knockout (PRLRJ/J), heterozygous (PRLR+/J), and wild-…
the NEO cassette (Ormandy, 1997a). Knockout (PRLRJ/J), heterozygous (PRLR+/J), and wild-…
Cyclin D1, EMS1 and 11q13 amplification in breast cancer
CJ Ormandy, EA Musgrove, R Hui, RJ Daly… - Breast cancer research …, 2003 - Springer
Chromosome locus 11q13 is frequently amplified in a number of human cancers including
carcinoma of the breast where up to 15% carry this chromosomal abnormality. Originally …
carcinoma of the breast where up to 15% carry this chromosomal abnormality. Originally …
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
Hormonal cues regulate mammary development, but the consequent transcriptional changes
and cell fate decisions are largely undefined. We show that knockout of the prolactin-…
and cell fate decisions are largely undefined. We show that knockout of the prolactin-…
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
The emerging standard of care for patients with inoperable pancreatic cancer is a combination
of cytotoxic drugs gemcitabine and Abraxane, but patient response remains moderate. …
of cytotoxic drugs gemcitabine and Abraxane, but patient response remains moderate. …
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue
Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased
with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can …
with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can …
Y4 receptor knockout rescues fertility in ob/ob mice
…, A Jenkins, SR Oakes, CJ Ormandy… - Genes & …, 2002 - genesdev.cshlp.org
Hypothalamic neuropeptide Y (NPY) has been implicated in the regulation of energy balance
and reproduction, and chronically elevated NPY levels in the hypothalamus are associated …
and reproduction, and chronically elevated NPY levels in the hypothalamus are associated …
Socs2 and elf5 mediate prolactin-induced mammary gland development
The proliferative phase of mammary alveolar morphogenesis is initiated during early pregnancy
by rising levels of serum prolactin and progesterone, establishing a program of gene …
by rising levels of serum prolactin and progesterone, establishing a program of gene …
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer
…, CM McNeil, A McFarland, A Nguyen, CJ Ormandy… - Cancer research, 2011 - AACR
Hedgehog (Hh) signaling plays an important role in several malignancies but its clinical
significance in breast cancer is unclear. In a cohort of 279 patients with invasive ductal …
significance in breast cancer is unclear. In a cohort of 279 patients with invasive ductal …