User profiles for Christopher J. P. Mathy
 | Christopher MathyPostdoc at Stanford Genetics Verified email at stanford.edu Cited by 5241 |
[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …
which is the causative agent of coronavirus disease 2019 (COVID-19), has …
[PDF][PDF] The global phosphorylation landscape of SARS-CoV-2 infection
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds …
[HTML][HTML] Emerging maps of allosteric regulation in cellular networks
CJP Mathy, T Kortemme - Current Opinion in Structural Biology, 2023 - Elsevier
Allosteric regulation is classically defined as action at a distance, where a perturbation outside
of a protein active site affects function. While this definition has motivated many studies of …
of a protein active site affects function. While this definition has motivated many studies of …
[PDF][PDF] A complete allosteric map of a GTPase switch in its native cellular network
Allosteric regulation is central to protein function in cellular networks. A fundamental open
question is whether cellular regulation of allosteric proteins occurs only at a few defined …
question is whether cellular regulation of allosteric proteins occurs only at a few defined …
Systems-level effects of allosteric perturbations to a model molecular switch
Molecular switch proteins whose cycling between states is controlled by opposing regulators
1 , 2 are central to biological signal transduction. As switch proteins function within highly …
1 , 2 are central to biological signal transduction. As switch proteins function within highly …
[HTML][HTML] A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design
JJ Baker, CJP Mathy, J Schaletzky - PLoS computational biology, 2021 - journals.plos.org
Resolving the Coronavirus Disease 2019 (CAU: PleasenotethatCOVID À
19hasbeendefinedasCoronavirusDisease20 OVID-19) pandemic is hamstrung by emerging Severe …
19hasbeendefinedasCoronavirusDisease20 OVID-19) pandemic is hamstrung by emerging Severe …
A complete allosteric map of a GTPase switch in its native network
Allosteric regulation is central to protein function in cellular networks 1 . However, despite
technological advances 2 , 3 most studies of allosteric effects on function are conducted in …
technological advances 2 , 3 most studies of allosteric effects on function are conducted in …
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication
Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and
replication in human liver cells. To search for novel host factor proteins required for HCV …
replication in human liver cells. To search for novel host factor proteins required for HCV …
A SARS-CoV-2-Human protein-Protein interaction map reveals drug targets and potential drug-repurposing (preprint)
…, D Memon, C Hernandez-Armenta, CJP Mathy… - 2020 - pesquisa.bvsalud.org
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19
respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, …
respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, …
A complete allosteric map of a GTPase switch in its native network [preprint]
Allosteric regulation is central to protein function in cellular networks1. However, despite
technological advances2,3 most studies of allosteric effects on function are conducted in …
technological advances2,3 most studies of allosteric effects on function are conducted in …