In complex biological systems, small molecules often mediate microbe-microbe and microbe-host
interactions. Using a systematic approach, we identified 3,118 small-molecule …

Inhibition of SHP2 causes direct and selective depletion of protumorigenic M2 macrophages
and promotes antitumor immunity, highlighting an investigational therapeutic approach for …

Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide
spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAF V600E -driven …

Cytological profiling is a high-content image-based screening technology that provides
insight into the mode of action (MOA) for test compounds by directly measuring hundreds of …

The discovery of small-molecule inhibitors requires suitable binding pockets on protein
surfaces. Proteins that lack this feature are considered undruggable and require innovative …

We evaluated the ability of the natural, plant-derived acaricides nootkatone and carvacrol to
suppress Ixodes scapularis Say and Amblyomma americanum (L.) (Acari: Ixodidae). …

Historically, marine invertebrates have been a prolific source of unique natural products, with
a diverse array of biological activities. Recent studies of invertebrate-associated microbial …

Marine natural products are an important source of lead compounds against many
pathogenic targets. Herein, we report the discovery of lobosamides A–C from a marine …

To evaluate their relative importance in tick-borne disease transmission in New Jersey, host-seeking
Amblyomma americanum (L.) and Ixodes scapularis Say adults and nymphs were …

Despite significant advances in antimalarial chemotherapy over the past 30 years,
development of resistance to frontline drugs remains a significant challenge that limits efforts to …