Down-regulation (degradation) of cell surface proteins within the lysosomal lumen depends
on the function of the multivesicular body (MVB) sorting pathway. The function of this …

Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures
defined as regions of the ER that tightly associate with the plasma membrane. However, little is …

The diversity of plasma membrane (PM) proteins presents a challenge for the achievement
of cargo-specific regulation of endocytosis. Here, we describe a family of proteins in yeast (…

Sac1 phosphoinositide (PI) phosphatases are essential regulators of PI-signaling networks.
Yeast Sac1, an integral endoplasmic reticulum (ER) membrane protein, controls PI4P levels …

Phosphoinositides (PI) are synthesized and turned over by specific kinases, phosphatases,
and lipases that ensure the proper localization of discrete PI isoforms at distinct membranes. …

Eukaryotic cells are divided into distinct membrane-bound organelles with unique identities
and specialized metabolic functions. Communication between organelles must take place to …

The Saccharomyces cerevisiae FAB1 gene encodes the sole phosphatidylinositol 3-phosphate
[PtdIns(3)P] 5-kinase responsible for synthesis of the polyphosphoinositide PtdIns(3,5)P …

Spatial organization of membranes into domains of distinct protein and lipid composition is
a fundamental feature of biological systems. The plasma membrane is organized in such …

Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma
membrane (PM) play fundamental roles in all eukaryotic cells. ER-PM MCS are particularly …

The Saccharomyces cerevisiae phosphatidylcholine/phosphatidylinositol transfer protein
Sec14p is required for Golgi apparatus-derived vesicular transport through coordinate …