Examining complete gene knockouts within a viable organism can inform on gene function.
We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental …

Humans are adept at inferring the mental states underlying other agents’ actions, such as
goals, beliefs, desires, emotions and other thoughts. We propose a computational framework …

Circadian clocks organize our inner physiology with respect to the external world, providing
life with the ability to anticipate and thereby better prepare for major fluctuations in its …

BACKGROUND & AIMS: Excessive postprandial lipemia is a prevalent condition that results
from intestinal oversecretion of apolipoprotein B48 (apoB48)-containing lipoproteins. …

Social cognition depends on our capacity for ‘mentalizing’, or explaining an agent’s behaviour
in terms of their mental states. The development and neural substrates of mentalizing are …

Circadian systems are comprised of multiple proteins functioning together to produce feedback
loops driving robust, approximately 24 hr rhythms. In all circadian systems, proteins in …

The pace has quickened in circadian biology research. In particular, an abundance of results
focused on post-translational modifications (PTMs) is sharpening our view of circadian …

In many mammals, including humans and mice, the zinc finger histone methyltransferase
PRDM9 performs the first step in meiotic recombination by specifying the locations of hotspots, …

In mammals, genetic recombination during meiosis is limited to a set of 1- to 2-kb regions
termed hotspots. Their locations are predominantly determined by the zinc finger protein …

Meiotic recombination generates new genetic variation and assures the proper segregation
of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase …