In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic
response characterized by increased myocardial cell size and activation of fetal cardiac genes. …

Environmental stresses converge on the mitochondria that can trigger or inhibit cell death.
Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms that …

The heart responds to stress signals by hypertrophic growth, which is accompanied by
activation of the MEF2 transcription factor and reprogramming of cardiac gene expression. We …

The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth
that frequently progresses to heart failure. The calcium/calmodulin-dependent protein …

β-Adrenergic receptor (βAR) signaling, which elevates intracellular cAMP and enhances
cardiac contractility, is severely impaired in the failing heart. Protein kinase A (PKA) is activated …

Postnatal cardiac myocytes respond to stress signals by hypertrophic growth and activation
of a fetal gene program. Recently, we showed that class II histone deacetylases (HDACs) …

Signaling events controlled by calcineurin promote cardiac hypertrophy, but the degree to
which such pathways are required to transduce the effects of various hypertrophic stimuli …

The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription
factors, has been implicated in diverse cellular responses, including the response to osmotic …

In vitro generation of cardiomyocytes (CMs) from human cells opens the possibility to
develop patient-specific therapies to various cardiomyopathies. By establishing the in vitro …

In response to stress signals, postnatal cardiomyocytes undergo hypertrophic growth
accompanied by activation of a fetal gene program, assembly of sarcomeres, and cellular …