Organelles, proteins, and mRNA are transported bidirectionally along microtubules by plus‐end
directed kinesin and minus‐end directed dynein motors. Microtubules are decorated by …

The motor proteins kinesin and dynein transport organelles, mRNA, proteins, and signaling
molecules along the microtubule cytoskeleton. In addition to serving as tracks for transport, …

The ability of Tau to act as a potent inhibitor of kinesin's processive run length in vitro suggests
that it may actively participate in the regulation of axonal transport in vivo. However, it …

The neck-linker is a structurally conserved region among most members of the kinesin
superfamily of molecular motor proteins that is critical for kinesin's processive transport of …

The kinesin-3 family member KIF1A plays a critical role in site-specific neuronal cargo delivery
during axonal transport. KIF1A cargo is mislocalized in many neurodegenerative diseases…

Microtubule-based axonal transport is tightly regulated by numerous pathways, ensuring
appropriate delivery of specific organelle cargoes to selected subcellular domains. Highlighting …

Disruptions in microtubule motor transport are associated with a variety of neurodegenerative
diseases. Post-translational modification of the cargo-binding domain of the light and …

It has been demonstrated that Tau exists on the microtubule lattice in both diffusing and static
populations, but how this may relate to Tau function is currently unclear. Tau isoforms are …

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP)
primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate …

The putative actin-binding interface of myosin is separated by a large cleft that extends into
the base of the nucleotide binding pocket, suggesting that it may be important for mediating …