The adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion
of adenosine to inosine (A to I) in primary mRNA transcripts, thereby affecting the splicing …

Checkpoint genes maintain genomic stability by arresting cells after DNA damage. Many of
these genes also control cell cycle events in unperturbed cells. By conducting a screen for …

Eukaryotes have numerous checkpoint pathways to protect genome fidelity during normal
cell division and in response to DNA damage. Through a screen for G2/M checkpoint …

ADAR2 is a double-stranded-RNA-specific adenosine deaminase involved in the editing of
mammalian RNAs by the site-selective conversion of adenosine to inosine. Previous studies …

Sister chromatids are tethered together by the cohesin complex from the time they are made
until their separation at anaphase. The ability of cohesin to tether sister chromatids together …

ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of
mammalian RNAs by the site-specific conversion of adenosine to inosine. We have …

During prophase of meiosis I, homologous chromosomes interact and undergo recombination.
Successful completion of these processes is required in order for the homologous …

In dividing cells, DNA replication occurs in a precise order, but many questions remain
regarding the mechanisms of replication timing establishment and regulation. We now have …

S-phase cyclin-dependent kinases (CDKs) stimulate replication initiation and accelerate
progression through the replication timing program, but it is unknown which CDK substrates are …

DNA replication origins in hyperacetylated euchromatin fire preferentially during early S
phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN …