Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling

CM Groen, AJ Spracklen, TN Fagan… - Molecular biology of the …, 2012 - Am Soc Cell Biol
Although prostaglandins (PGs)—lipid signals produced downstream of cyclooxygenase (COX)
enzymes—regulate actin cytoskeletal dynamics, their mechanisms of action are unknown…

Genetic reduction of mitochondria complex I subunits is protective against cisplatin-induced neurotoxicity in Drosophila

CM Groen, JL Podratz, J Pathoulas, N Staff… - Journal of …, 2022 - Soc Neuroscience
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent side effect of widely
used platinum-based anticancer agents. There are few predictable risk factors with which to …

Fascin regulates nuclear actin during Drosophila oogenesis

DJ Kelpsch, CM Groen, TN Fagan… - Molecular biology of …, 2016 - Am Soc Cell Biol
Drosophila oogenesis provides a developmental system with which to study nuclear actin.
During Stages 5–9, nuclear actin levels are high in the oocyte and exhibit variation within the …

The evolving regulatory landscape in regenerative medicine

DJ Beetler, DN Di Florio, EW Law, CM Groen… - Molecular aspects of …, 2023 - Elsevier
Regenerative medicine as a field has emerged as a new component of modern medicine
and medical research that encompasses a wide range of products including cellular and …

Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture

CM Groen, A Jayo, M Parsons… - Molecular biology of the …, 2015 - Am Soc Cell Biol
Fascin, a highly conserved actin-bundling protein, localizes and functions at new cellular
sites in both Drosophila and multiple mammalian cell types. During Drosophila follicle …

Pharmaco-Genetic Screen To Uncover Actin Regulators Targeted by Prostaglandins During Drosophila Oogenesis

AJ Spracklen, MC Lamb, CM Groen… - G3: Genes, Genomes …, 2019 - academic.oup.com
Prostaglandins (PGs) are lipid signaling molecules with numerous physiologic functions,
including pain/inflammation, fertility, and cancer. PGs are produced downstream of …

Drosophila strain specific response to cisplatin neurotoxicity

CM Groen, JL Podratz, K Treb, AJ Windebank - Fly, 2018 - Taylor & Francis
Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model
of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent …

Mini-course-based undergraduate research experience

…, AK Allen, AJ Spracklen, CM Groen… - Journal of College …, 2019 - JSTOR
Undergraduate research experiences (UREs) increase interest in STEM (science, technology,
engineering, and mathematics) research and careers. UREs are utilized as recruitment …

Promoting international collaboration and creativity in doctoral students

CM Groen, C McGrath, KA Campbell, C Götherström… - ELife, 2017 - elifesciences.org
CHRISTOPHER M GROEN, CORMAC MCGRATH, KATHERINE A CAMPBELL, CECILIA
GO THERSTRO M, ANTHONY J WINDEBANK AND NATALIA LANDA ZURI* … Copyright …

Visualization of Actin Cytoskeletal Dynamics in Fixed and Live Drosophila Egg Chambers

CM Groen, TL Tootle - Drosophila Oogenesis: Methods and Protocols, 2015 - Springer
Visualization of actin cytoskeletal dynamics is critical for understanding the spatial and
temporal regulation of actin remodeling. Drosophila oogenesis provides an excellent model …