User profiles for Christopher Naranjo

Christopher Naranjo

MD Candidate, Vanderbilt University School of Medicine
Verified email at vanderbilt.edu
Cited by 78

[HTML][HTML] Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

H Xu, RM Fame, C Sadegh, J Sutin, C Naranjo… - Nature …, 2021 - nature.com
Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation,
such as hydrocephalus, can negatively affect perinatal neurodevelopment. The mechanisms …

SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques

…, F Nampanya, S Patel, L Bowman, CA Naranjo… - Science …, 2022 - science.org
Authorized vaccines against SARS-CoV-2 remain less available in low- and middle-income
countries due to insufficient supply, high costs, and storage requirements. Global immunity …

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

…, M Silva, RS Johnston, CA Naranjo… - Proceedings of the …, 2021 - National Acad Sciences
Global containment of COVID-19 still requires accessible and affordable vaccines for low-
and middle-income countries (LMICs). Recently approved vaccines provide needed …

Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2

…, J Yu, A Chang, C Nakao, B Goodwin, CA Naranjo… - Science …, 2021 - science.org
There is a need for additional rapidly scalable, low-cost vaccines against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) to achieve global vaccination. Aluminum …

Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffii

…, SA Rodriguez‐Aponte, CA Naranjo… - Biotechnology and …, 2022 - Wiley Online Library
Prevention of COVID‐19 on a global scale will require the continued development of high‐volume,
low‐cost platforms for the manufacturing of vaccines to supply ongoing demand. …

[HTML][HTML] Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters

…, KA Rodrigues, M Silva, RS Johnston, CA Naranjo… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Global containment of COVID-19 still requires accessible and affordable vaccines for low-and
middle-income countries (LMICs). 1 Recently approved vaccines provide needed …

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG …

…, NC Dalvie, CA Naranjo… - Human Vaccines & …, 2022 - Taylor & Francis
Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve
vaccine coverage in low- and middle-income countries. To this end, subunit-based approaches …

[HTML][HTML] A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

…, F Nampanya, S Patel, L Bowman, CA Naranjo… - bioRxiv, 2021 - ncbi.nlm.nih.gov
Vaccines against SARS-CoV-2 have been distributed at massive scale in developed countries,
and have been effective at preventing COVID-19. Access to vaccines is limited, however, …

[HTML][HTML] Association of hypothermia with increased mortality rate in SARS-CoV-2 infection

…, RG Santos, R Zeidan, AP Gastesi, CD Naranjo - International Journal of …, 2021 - Elsevier
Objective Patients were observed to have variable temperatures. The objective of this study
was to identify whether hypothermia in a patient infected with SARS-CoV-2 was associated …

An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies

…, Z An, S Patel, S Rodriguez-Aponte, CA Naranjo… - bioRxiv, 2023 - biorxiv.org
Blood-based, or “liquid,” biopsies enable minimally invasive diagnostics but have limits on
sensitivity due to scarce cell-free DNA (cfDNA). Improvements to sensitivity have primarily …