User profiles for Christopher R. Vakoc
 | Christopher VakocCold Spring Harbor Laboratory Verified email at cshl.edu Cited by 25907 |
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9–…
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9–…
[HTML][HTML] BET bromodomain inhibition as a therapeutic strategy to target c-Myc
…, AC Schinzel, MR McKeown, TP Heffernan, CR Vakoc… - Cell, 2011 - cell.com
MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to
modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have …
modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have …
[HTML][HTML] Selective inhibition of tumor oncogenes by disruption of super-enhancers
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear
why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. …
why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. …
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin
modifications. Cancer cells are characterized by altered epigenetic landscapes, and …
modifications. Cancer cells are characterized by altered epigenetic landscapes, and …
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …
[PDF][PDF] Histone H3 lysine 9 methylation and HP1γ are associated with transcription elongation through mammalian chromatin
CR Vakoc, SA Mandat, BA Olenchock, GA Blobel - Molecular cell, 2005 - cell.com
Methylation of histones modulates chromatin structure and function. Whereas methylation of
histone H3 on lysines 4, 36, and 79 has been linked with gene activation, methylation of H3 …
histone H3 on lysines 4, 36, and 79 has been linked with gene activation, methylation of H3 …
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
[HTML][HTML] The mechanisms behind the therapeutic activity of BET bromodomain inhibition
The bromodomain and extraterminal (BET) protein Brd4 recruits transcriptional regulatory
complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional …
complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional …
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification in both coding 1
and non-coding RNAs 2 , 3 that is catalysed by the METTL3–METTL14 methyltransferase …
and non-coding RNAs 2 , 3 that is catalysed by the METTL3–METTL14 methyltransferase …
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
…, M Schupp, D Zhuo, AL Vakoc… - … and cellular biology, 2008 - Taylor & Francis
The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic
pattern of gene expression through binding with several MLL fusion partners found in acute …
pattern of gene expression through binding with several MLL fusion partners found in acute …