Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Estimating individual genome-wide autozygosity is important both in the identification of
recessive disease variants via homozygosity mapping and in the investigation of the effects of …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …

In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have
been identified in recent genome-wide association studies (GWAS). To identify additional loci, …

The human genome is characterised by many runs of homozygous genotypes, where identical
haplotypes were inherited from each parent. The length of each run is determined partly …

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids
are required for active transport, a number of enzymatic processes, membrane formation, and …

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health.
In genome-wide association meta-analysis of European and Central Asian mothers, we …

Sphingolipids have essential roles as structural components of cell membranes and in cell
signalling, and disruption of their metabolism causes several diseases, with diverse …