[HTML][HTML] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance
and be therapeutically targeted. Compared to normal cells, several human cancers have …
and be therapeutically targeted. Compared to normal cells, several human cancers have …
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
LR You, FJ Lin, CT Lee, FJ DeMayo, MJ Tsai, SY Tsai - Nature, 2005 - nature.com
Arteries and veins are anatomically, functionally and molecularly distinct. The current model
of arterial–venous identity proposes that binding of vascular endothelial growth factor to its …
of arterial–venous identity proposes that binding of vascular endothelial growth factor to its …
[HTML][HTML] Identifying and interrupting superspreading events—implications for control of severe acute respiratory syndrome coronavirus 2
TR Frieden, CT Lee - Emerging infectious diseases, 2020 - ncbi.nlm.nih.gov
It appears inevitable that severe acute respiratory syndrome coronavirus 2 will continue to
spread. Although we still have limited information on the epidemiology of this virus, there have …
spread. Although we still have limited information on the epidemiology of this virus, there have …
Evaluation of the potential of Hyperion for fire danger assessment by comparison to the Airborne Visible/Infrared Imaging Spectrometer
Parameters derived from remote sensing that can be used to assess fire danger include surface
reflectance, live and dead biomass, canopy water content, species composition, and fuel …
reflectance, live and dead biomass, canopy water content, species composition, and fuel …
Anatomy-specific classification of medical images using deep convolutional nets
Automated classification of human anatomy is an important prerequisite for many computer-aided
diagnosis systems. The spatial complexity and variability of anatomy throughout the …
diagnosis systems. The spatial complexity and variability of anatomy throughout the …
Simulation-based approaches for determining membrane permeability of small compounds
Predicting the rate of nonfacilitated permeation of solutes across lipid bilayers is important
to drug design, toxicology, and signaling. These rates can be estimated using molecular …
to drug design, toxicology, and signaling. These rates can be estimated using molecular …
Emerging computational methods for the rational discovery of allosteric drugs
Allosteric drug development holds promise for delivering medicines that are more selective
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …
Geriatric conditions in a population-based sample of older homeless adults
RT Brown, K Hemati, ED Riley, CT Lee… - The …, 2017 - academic.oup.com
Purpose of the Study: Older homeless adults living in shelters have high rates of geriatric
conditions, which may increase their risk for acute care use and nursing home placement. …
conditions, which may increase their risk for acute care use and nursing home placement. …
[HTML][HTML] 7-1-7: an organising principle, target, and accountability metric to make the world safer from pandemics
TR Frieden, CT Lee, AF Bochner, M Buissonnière… - The Lancet, 2021 - thelancet.com
COVID-19 makes it both possible and necessary to review lessons learnt from recent epidemics,
re-evaluate approaches, and develop a framework that accelerates progress to make …
re-evaluate approaches, and develop a framework that accelerates progress to make …
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …