User profiles for Christopher T Lee

Christopher T. Lee

- Verified email at post.harvard.edu - Cited by 1865

Christopher T. Lee

- Verified email at ucsd.edu - Cited by 911

Christopher T. Lee

- Verified email at csulb.edu - Cited by 395

[HTML][HTML] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

…, A Haromy, C Beaulieu, R Thompson, CT Lee… - Cancer cell, 2007 - cell.com
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance
and be therapeutically targeted. Compared to normal cells, several human cancers have …

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity

LR You, FJ Lin, CT Lee, FJ DeMayo, MJ Tsai, SY Tsai - Nature, 2005 - nature.com
Arteries and veins are anatomically, functionally and molecularly distinct. The current model
of arterial–venous identity proposes that binding of vascular endothelial growth factor to its …

[HTML][HTML] Identifying and interrupting superspreading events—implications for control of severe acute respiratory syndrome coronavirus 2

TR Frieden, CT Lee - Emerging infectious diseases, 2020 - ncbi.nlm.nih.gov
It appears inevitable that severe acute respiratory syndrome coronavirus 2 will continue to
spread. Although we still have limited information on the epidemiology of this virus, there have …

Evaluation of the potential of Hyperion for fire danger assessment by comparison to the Airborne Visible/Infrared Imaging Spectrometer

…, Y Hetzel, SL Ustin, CT Lee - … on Geoscience and …, 2003 - ieeexplore.ieee.org
Parameters derived from remote sensing that can be used to assess fire danger include surface
reflectance, live and dead biomass, canopy water content, species composition, and fuel …

Anatomy-specific classification of medical images using deep convolutional nets

HR Roth, CT Lee, HC Shin, A Seff, L Kim… - 2015 IEEE 12th …, 2015 - ieeexplore.ieee.org
Automated classification of human anatomy is an important prerequisite for many computer-aided
diagnosis systems. The spatial complexity and variability of anatomy throughout the …

Simulation-based approaches for determining membrane permeability of small compounds

CT Lee, J Comer, C Herndon, N Leung… - Journal of chemical …, 2016 - ACS Publications
Predicting the rate of nonfacilitated permeation of solutes across lipid bilayers is important
to drug design, toxicology, and signaling. These rates can be estimated using molecular …

Emerging computational methods for the rational discovery of allosteric drugs

JR Wagner, CT Lee, JD Durrant, RD Malmstrom… - Chemical …, 2016 - ACS Publications
Allosteric drug development holds promise for delivering medicines that are more selective
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …

Geriatric conditions in a population-based sample of older homeless adults

RT Brown, K Hemati, ED Riley, CT Lee… - The …, 2017 - academic.oup.com
Purpose of the Study: Older homeless adults living in shelters have high rates of geriatric
conditions, which may increase their risk for acute care use and nursing home placement. …

[HTML][HTML] 7-1-7: an organising principle, target, and accountability metric to make the world safer from pandemics

TR Frieden, CT Lee, AF Bochner, M Buissonnière… - The Lancet, 2021 - thelancet.com
COVID-19 makes it both possible and necessary to review lessons learnt from recent epidemics,
re-evaluate approaches, and develop a framework that accelerates progress to make …

Transcriptional Regulatory Networks in Saccharomyces cerevisiae

TI Lee, NJ Rinaldi, F Robert, DT Odom, Z Bar-Joseph… - science, 2002 - science.org
We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …