User profiles for Christopher T. Workman

Christopher T. Workman

Technical University of Denmark, Department of Biotechnology and Biomedicine
Verified email at dtu.dk
Cited by 14907

A scored human protein–protein interaction network to catalyze genomic interpretation

…, H Horn, J Mercer, G Slodkowicz, CT Workman… - Nature …, 2017 - nature.com
Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …

Modeling regulatory networks with weight matrices

DC Weaver, CT Workman, GD Stormo - Biocomputing'99, 1999 - World Scientific
Systematic gene expression analyses provide comprehensive information about the
transcriptional response to different environmental and developmental conditions. With enough …

[HTML][HTML] Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans

…, N Jørgensen, VB Kristiansen, T Hansen, CT Workman… - Cell metabolism, 2016 - cell.com
Obesity is a heritable disorder, with children of obese fathers at higher risk of developing
obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of …

Evolutionary dynamics of bacteria in a human host environment

…, RL Marvig, S Damkiær, CT Workman… - Proceedings of the …, 2011 - National Acad Sciences
Laboratory evolution experiments have led to important findings relating organism adaptation
and genomic evolution. However, continuous monitoring of long-term evolution has been …

A systems approach to mapping DNA damage response pathways

CT Workman, HC Mak, S McCuine, JB Tagne… - Science, 2006 - science.org
Failure of cells to respond to DNA damage is a primary event associated with mutagenesis
and environmental toxicity. To map the transcriptional network controlling the damage …

enoLOGOS: a versatile web tool for energy normalized sequence logos

CT Workman, Y Yin, DL Corcoran, T Ideker… - Nucleic acids …, 2005 - academic.oup.com
enoLOGOS is a web-based tool that generates sequence logos from various input sources.
Sequence logos have become a popular way to graphically represent DNA and amino acid …

[HTML][HTML] The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans

…, NA Pudlo, R Glowacki, G Pereira, CT Workman… - Nature …, 2019 - nature.com
β-Mannans are plant cell wall polysaccharides that are commonly found in human diets.
However, a mechanistic understanding into the key populations that degrade this glycan is …

ANN-Spec: a method for discovering transcription factor binding sites with improved specificity

CT Workman, GD Stormo - Biocomputing 2000, 1999 - World Scientific
This work describes ANN-Spec, a machine learning algorithm and its application to discovering
un-gapped patterns in DNA sequence. The approach makes use of an Artificial Neural …

15‐year follow‐up of the Second Nordic Mantle Cell Lymphoma trial (MCL 2): prolonged remissions without survival plateau

…, CT Workman… - British journal of …, 2016 - Wiley Online Library
In recent decades, the prognosis of Mantle Cell Lymphoma ( MCL ) has been significantly
improved by intensified first‐line regimens containing cytarabine, rituximab and consolidation …

[HTML][HTML] Robust estimation of bacterial cell count from optical density

…, Delgado-Ivy-Marin Ahlgren Christopher 49 … - Communications …, 2020 - nature.com
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but
cannot be compared between instruments without a standardized calibration protocol and is …