BackgroundA comparison of the performance of the 5-item mental health dimension of SF–36
(MHI–5) with that of the 12-item General Health Questionnaire (GHQ–12) in a defined, non-…

Graves’ disease (GD) is a common autoimmune disease (AID) that shares many of its
susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the …

As tensions between payers, responsible for ensuring prudent and principled use of scarce
resources, and both providers and patients, who legitimately want access to technologies …

Background Basic fibroblast growth factor promotes angiogenesis and mitogenesis in colon
carcinomas. Pituitarytumour transforming gene (PTTG 1 ) causes in-vitro and in-vivo …

Down’s syndrome (DS) is a genetic disorder caused by full or partial trisomy of human
chromosome 21 and presents with many clinical phenotypes including a reduced incidence of …

The development of the human placenta involves a complex process of tightly regulated
proliferation and invasion by extravillous trophoblast into the uterine decidua. Inadequate …

Differentiated thyroid cancers and their metastases frequently exhibit reduced iodide uptake,
impacting on the efficacy of radioiodine ablation therapy. PTTG binding factor (PBF) is a …

We have described the expression of specific iodothyronine deiodinase mRNAs (using
quantitative RT-PCR) and activities in normal human placentas throughout gestation and …

Background Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) genome editing have led to the use of long …

There is an inevitable tension between robust reimbursement processes and providing speedy
access to new and novel technologies, given uncertainties about key pieces of evidence …