Multivalent ligands can function as inhibitors or effectors of biological processes. Potent
inhibitory activity can arise from the high functional affinities of multivalent ligand−receptor …

Receptor clustering by multivalent ligands can activate signaling pathways. In principle,
multivalent ligand features can control clustering and the downstream signals that result, but the …

The plasma membrane of cells contains a diverse array of lipids that provide important
structural and biological features. Glycolipids are typically a minor component of the cell …

The function of cellular membranes remains a critical area of study. Advances in molecular
biology and biochemistry have helped to define the plasma membrane as a dynamic and …

The extraction of hidden information from complex trajectories is a continuing problem in
single-particle and single-molecule experiments. Particle trajectories are the result of multiple …

The human neuraminidase enzymes (hNEU) are a family of four isoenzymes that hydrolyze
sialosides, including gangliosides and glycoproteins. These enzymes are proposed to play …

The α L β 2 integrin (leukocyte function-associated antigen-1 [LFA-1]) is regulated to engage
and maintain T cell adhesion. Conformational changes in the receptor are associated with …

One of the principal goals of glycoprotein research is to correlate glycan structure and function.
Such correlation is necessary in order for one to understand the mechanisms whereby …

Strategies for interfering with protein aggregation are important for elucidating and controlling
the pathologies of amyloid diseases. We have previously identified compounds that block …

The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by
a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes…