Fracture healing involves interactions of different cell types, driven by various growth factors,
and signaling cascades. Periosteal mesenchymal progenitor cells give rise to the majority …

The four receptors of the Notch family are widely expressed transmembrane proteins that
function as key conduits through which mammalian cells communicate to regulate cell fate and …

Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi. By targeting
internalizing cell surface antigens, antibody–siRNA complexes provide a possible solution. …

The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and
sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked …

SR protein kinases (SRPKs) and their substrates, the SR family of serine/arginine-rich pre-mRNA
splicing factors, appear to be key regulators of alternative splicing. Although SR …

Within the Kharta area, east of Mount Qomolangma (Everest), garnet sillimanite gneisses
and granites including mafic lenses that form the Greater Himalayan Sequence (GHS) were …

The Grønnedal-Ika complex is dominated by layered nepheline syenites which were intruded
by a xenolithic syenite and a central plug of calcite to calcite–siderite carbonatite. Aegirine–…

Arginine methylation is a prevalent modification found in many RNA binding proteins, yet little
is known about its functional consequences. Using a monoclonal antibody, 1E4, we have …

Strontium isotope analysis on human remains from the Iron Age (4th/3rd century BC) cemeteries
of Nebringen, Germany and Monte Bibele, Italy were carried out to investigate the role …

Objective We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate
stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Design Mice …