Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted
senescence-associated secretory phenotype (SASP). Loss of mitochondrial function …

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Cellular senescence is a process that results from a variety of stresses, leading to a state of
irreversible growth arrest. Senescent cells accumulate during aging and have been …

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and
its associated diseases. However, the mechanism for this decline is unclear. Here, we show …

Background and Objectives: Ultrasound-guided regional anesthesia is a rapidly growing
field. There exists little information regarding the competencies involved with such a practice. …

Cellular senescence is a complex stress response that permanently arrests the proliferation
of cells at risk for oncogenic transformation. However, senescent cells can also drive …

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …

Senescent cells play important roles in both physiological and pathological processes, including
cancer and aging. In all cases, however, senescent cells comprise only a small fraction …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent cells…

Rationale Age‐related changes in the intervertebral discs are the predominant contributors
to back pain, a common physical and functional impairment experienced by older persons. …