Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in …
…, K Hughes, E Huang, C de Bakker… - The Lancet Infectious …, 2020 - thelancet.com
Background The monoclonal antibody m102.4 is a potent, fully human antibody that
neutralises Hendra and Nipah viruses in vitro and in vivo. We aimed to investigate the safety, …
neutralises Hendra and Nipah viruses in vitro and in vivo. We aimed to investigate the safety, …
Overcoming instability of antibody‐nanomaterial conjugates: next generation targeted nanomedicines using bispecific antibodies
Targeted nanomaterials promise improved therapeutic efficacy, however their application in
nanomedicine is limited due to complexities associated with protein conjugations to …
nanomedicine is limited due to complexities associated with protein conjugations to …
[HTML][HTML] A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens
…, RA Gonzalez Garcia, C De Bakker… - Frontiers in …, 2019 - frontiersin.org
Acetogens can fix carbon (CO or CO 2 ) into acetyl-CoA via the Wood–Ljungdahl pathway (WLP)
that also makes them attractive cell factories for the production of fuels and chemicals …
that also makes them attractive cell factories for the production of fuels and chemicals …
Development of a protein nanoparticle platform for targeting EGFR expressing cancer cells
…, CB Howard, CJ de Bakker… - Journal of Chemical …, 2015 - Wiley Online Library
BACKGROUND A range of protein‐based nanoparticles has been developed for cancer
drug delivery and diagnostics. This includes the E2 protein derived from the pyruvate …
drug delivery and diagnostics. This includes the E2 protein derived from the pyruvate …
[HTML][HTML] Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models
…, N Vanegas, J Weiss, JH Suurbach, CJ De Bakker… - PLoS …, 2017 - journals.plos.org
Human malignant mesothelioma is a chemoresistant tumour that develops from mesothelial
cells, commonly associated with asbestos exposure. Malignant mesothelioma incidence …
cells, commonly associated with asbestos exposure. Malignant mesothelioma incidence …
Determination of petroleum properties by fiber-optic fourier transform raman spectrometry and partial least-squares analysis
CJ de Bakker, PM Fredericks - Applied spectroscopy, 1995 - journals.sagepub.com
The petroleum products unleaded gasoline and reformate have been analyzed by Fourier
transform (FT) Raman spectrometry with the use of a fiber optic cable that allows a …
transform (FT) Raman spectrometry with the use of a fiber optic cable that allows a …
[HTML][HTML] Beyond antibodies: Development of a novel protein scaffold based on human chaperonin 10
AM Alsultan, DY Chin, CB Howard, CJ de Bakker… - Scientific Reports, 2016 - nature.com
Human Chaperonin 10 (hCpn10) was utilised as a novel scaffold for presenting peptides of
therapeutic and diagnostic significance. Molecular dynamic simulations and protein sizing …
therapeutic and diagnostic significance. Molecular dynamic simulations and protein sizing …
[HTML][HTML] Canine CD117-specific antibodies with diverse binding properties isolated from a phage display library using cell-based biopanning
MA Alfaleh, N Arora, M Yeh, CJ de Bakker, CB Howard… - Antibodies, 2019 - mdpi.com
CD117 (c-Kit) is a tyrosine kinase receptor that is overexpressed in multiple dog tumors.
There is 100% homology between the juxtamembrane domain of human and canine CD117, …
There is 100% homology between the juxtamembrane domain of human and canine CD117, …
Targeted Nanomaterials: Overcoming Instability of Antibody‐Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv …
Christopher B. Howard, and co-workers report the generation of targeted nanomaterials for
cancer theranostics by mixing of hyperbranched polyethylene glycol polymers with bispecific …
cancer theranostics by mixing of hyperbranched polyethylene glycol polymers with bispecific …
In-situ characterization by FT-Raman spectroscopy of compounds separated on a thin layer chromatography plate
P Fredericks, C de Bakker… - 8th Intl Conf on Fourier …, 1992 - spiedigitallibrary.org
FT-Raman spectroscopy has been shown to be useful as a method of identifying compounds
separated on a tlc plate. Commercial tlc plates, with or without UV fluorescent indicators, …
separated on a tlc plate. Commercial tlc plates, with or without UV fluorescent indicators, …