Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM)
family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. …

To initiate DNA replication, the origin recognition complex (ORC) and Cdc6 load an Mcm2–7
double hexamer onto DNA. Without ATP hydrolysis, ORC–Cdc6 recruits one Cdt1-bound …

The RNA binding proteome ( RBP ome) was previously investigated using UV crosslinking
and purification of poly(A)‐associated proteins. However, most cellular transcripts are not …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal
complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and …

Cellular responses to environmental stress are frequently mediated by RNA-binding
proteins (RBPs). Here, we examined global RBP dynamics in Saccharomyces cerevisiae in …

CDK4/6 inhibitors arrest the cell cycle in G1‐phase. They are approved to treat breast cancer
and are also undergoing clinical trials against a range of other tumour types. To facilitate …

The presence and absence of RNA modifications regulates RNA metabolism by modulating
the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m 5 C) however, it is …

From biosynthesis to assembly into nucleosomes, histones are handed through a cascade
of histone chaperones, which shield histones from non-specific interactions. Whether …

Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics
and mutated in a wide range of human diseases. Yet little is known about the molecular …