The aggregation of proteins into oligomers and amyloid fibrils is characteristic of several
neurodegenerative diseases, including Parkinson disease (PD). In PD, the process of …

Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide
spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAF V600E -driven …

X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase apoptotic activity.
XIAP also functions as an E3 ubiquitin ligase, targeting caspases for degradation. However, …

K + channels conduct and regulate K + flux across the cell membrane. Several crystal structures
and biophysical studies of tetrameric ion channels have revealed many of the structural …

Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with
other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric …

Glycogen is the primary energy reserve in mammals, and dysregulation of glycogen
metabolism can result in glycogen storage diseases (GSDs). In muscle, glycogen synthesis is …

Because membrane proteins need to be extracted from their natural environment and
reconstituted in artificial milieus for the 3D structure determination by X-ray crystallography or NMR…

Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays
a central role in energy homeostasis and has been proposed as a therapeutic target in …

The adhesion of the pathogen Neisseria meningitidis to host cell surface proteoglycan,
mediated by the integral outer membrane proteins OpcA and Opa, plays an important part in the …

Type IV pili are long, thin fibres, which extend from the surface of the bacterial pathogen
Neisseria meningitidis; they play a key role in adhesion and colonisation of host cells. PilP is a …