Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new
platform to investigate human brain development. High cost, variability, and tissue …

The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and
microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing …

In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …

Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities.
How ZIKV impairs brain development and function is unclear. Here we systematically …

Zika virus (ZIKV) infection attenuates the growth of human neural progenitor cells (hNPCs).
As these hNPCs generate the cortical neurons during early brain development, the ZIKV-…

Zika virus (ZIKV) and dengue virus (DENV) are two closely related flaviviruses that lead to
different clinical outcomes. The mechanism for the distinct pathogenesis of ZIKV and DENV is …

Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital
microcephaly and other birth defects. Flaviviruses, including ZIKV, reorganize the endoplasmic …

The molecular mechanism of the hepatic tropism of hepatitis C virus (HCV) remains incompletely
defined. In vitro hepatic differentiation of pluripotent stem cells produces hepatocyte-…

Individuals chronically infected with hepatitis C virus (HCV) commonly exhibit hepatic
intracellular lipid accumulation, termed steatosis. HCV infection perturbs host lipid metabolism …

Zika virus (ZIKV), a little-known flavivirus until a few months ago, is currently at the forefront
of public health concerns worldwide because of its suspected role in causing microcephaly …