Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent
cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity …

Background At least 75% of head and neck cancers are attributable to a combination of
cigarette smoking and alcohol drinking. A precise understanding of the independent association …

Lung cancer is the most common cause of cancer death worldwide, with over one million
cases annually 1 . To identify genetic factors that modify disease risk, we conducted a genome-…

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Background: The magnitude of risk conferred by the interaction between tobacco and alcohol
use on the risk of head and neck cancers is not clear because studies have used various …

Approximate nearest neighbor search is an efficient strategy for large-scale image retrieval.
Encouraged by the recent advances in convolutional neural networks (CNNs), we propose …

Purpose Endometrial cancers have long been divided into estrogen-dependent type I and
the less common clinically aggressive estrogen-independent type II. Little is known about risk …

Background Although the Women's Health Initiative (WHI) trial of estrogen plus progestin in
postmenopausal women identified more overall health risks than benefits among women in …

Background The human leukocyte antigen (HLA) system is widely used as a strategy in the
search for the etiology of infectious diseases and autoimmune disorders. During the Taiwan …

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159
controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease …