X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human
suffering. To date, no effective drug is available to directly treat the disease. In a search for …
suffering. To date, no effective drug is available to directly treat the disease. In a search for …
Macrophage‐disguised manganese dioxide nanoparticles for neuroprotection by reducing oxidative stress and modulating inflammatory microenvironment in acute …
…, B Su, H You, T Zhang, X Li, H Song, C Li… - Advanced …, 2021 - Wiley Online Library
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic
stroke. However, the current clinical treatments are remained on single pathological process, …
stroke. However, the current clinical treatments are remained on single pathological process, …
Biomimetic Dendrimer–Peptide Conjugates for Early Multi‐Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation
…, Z Zhao, Y Luo, X Li, H Song, B Su, C Li… - Advanced …, 2021 - Wiley Online Library
Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on β‐amyloid
(Aβ) targeting. However, such therapeutic strategies have limited clinical outcomes …
(Aβ) targeting. However, such therapeutic strategies have limited clinical outcomes …
Sequentially triggered bacterial outer membrane vesicles for macrophage metabolism modulation and tumor metastasis suppression
Q Guo, X Li, W Zhou, Y Chu, Q Chen, Y Zhang, C Li… - ACS …, 2021 - ACS Publications
Metabolic interactions between different cell types in the tumor microenvironment (TME)
often result in reprogramming of the metabolism to be totally different from their normal …
often result in reprogramming of the metabolism to be totally different from their normal …
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity
The human MT 1 and MT 2 melatonin receptors 1 , 2 are G-protein-coupled receptors (GPCRs)
that help to regulate circadian rhythm and sleep patterns 3 . Drug development efforts …
that help to regulate circadian rhythm and sleep patterns 3 . Drug development efforts …
Early-stage dynamics of chloride ion–pumping rhodopsin revealed by a femtosecond X-ray laser
Chloride ion–pumping rhodopsin (ClR) in some marine bacteria utilizes light energy to actively
transport Cl − into cells. How the ClR initiates the transport is elusive. Here, we show the …
transport Cl − into cells. How the ClR initiates the transport is elusive. Here, we show the …
Native phasing of x-ray free-electron laser data for a G protein–coupled receptor
Serial femtosecond crystallography (SFX) takes advantage of extremely bright and ultrashort
pulses produced by x-ray free-electron lasers (XFELs), allowing for the collection of high-…
pulses produced by x-ray free-electron lasers (XFELs), allowing for the collection of high-…
Smart hypoxia-responsive transformable and charge-reversible nanoparticles for the deep penetration and tumor microenvironment modulation of pancreatic cancer
…, Y Wang, Y Luo, Z Zhou, T Zhang, H Song, X Li, C Li… - Biomaterials, 2022 - Elsevier
The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the
major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong …
major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong …
Ultrafast structural changes within a photosynthetic reaction centre
Photosynthetic reaction centres harvest the energy content of sunlight by transporting electrons
across an energy-transducing biological membrane. Here we use time-resolved serial …
across an energy-transducing biological membrane. Here we use time-resolved serial …
Transcytosis mediated deep tumor penetration for enhanced chemotherapy and immune activation of pancreatic cancer
…, C Li, Y Wang, J Liu, F Luo, H Fan, X Li… - Advanced Functional …, 2023 - Wiley Online Library
The hyperproliferative tumor stroma of pancreatic ductal adenocarcinoma (PDAC) severely
limits drug permeation and constructs an immunosuppressive microenvironment, causing …
limits drug permeation and constructs an immunosuppressive microenvironment, causing …