Self-resolving inflammatory exudates and lipid mediator metabolomics recently uncovered
a new family of potent anti-inflammatory and proresolving mediators biosynthesized by …

Endogenous pain-inhibitory substances have rarely been found. A group of powerful pain
suppressor molecules that are endogenously generated are now emerging: resolvins and …

Intracellular microRNAs (miRNAs) are key regulators of gene expression. The role of
extracellular miRNAs in neuronal activation and sensory behaviors are unknown. Here we report …

Accumulating evidence suggests that spinal cord astrocytes play an important role in
neuropathic pain sensitization by releasing astrocytic mediators (eg cytokines, chemokines and …

Although acute inflammatory responses are host-protective and generally self-limited,
unresolved and delayed resolution of acute inflammation can lead to further tissue damage and …

Inflammatory pain such as arthritic pain is typically treated with opioids and cyclo-oxygenase-2
inhibitors with well known side effects. Transient receptor potential subtype vanilloid 1 (…

Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We
found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory …

Dry eye disease (DED) is one of the major ophthalmological healthcare challenges worldwide.
DED is a multifactorial disease characterized by a loss of homeostasis of the tear film, …

Voltage-gated sodium (Na V ) channels control the upstroke of the action potentials in
excitable cells. Multiple studies have shown distinct roles of Na V channel subtypes in human …

Mechanisms of inflammatory pain are not fully understood. We investigated the role of TRPV1
(transient receptor potential subtype V1) and TNF-α, two critical mediators for inflammatory …