Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including
autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags …
autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags …
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
[HTML][HTML] TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …
genetic architecture. However, little is known about how genetic variants impart brain …
Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community
Objectives : The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker
of cardiac fibrosis, with incident heart failure (HF) in the community. Background : Gal-3 is an …
of cardiac fibrosis, with incident heart failure (HF) in the community. Background : Gal-3 is an …
Epigenetic signatures of cigarette smoking
Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…
[HTML][HTML] Removing batch effects in analysis of expression microarray data: an evaluation of six batch adjustment methods
The expression microarray is a frequently used approach to study gene expression on a
genome-wide scale. However, the data produced by the thousands of microarray studies …
genome-wide scale. However, the data produced by the thousands of microarray studies …
[HTML][HTML] Genetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …