The aggregation of Aβ42 is a hallmark of Alzheimer’s disease. It is still not known what the
biochemical changes are inside a cell which will eventually lead to Aβ42 aggregation. …

The solvation shell is essential for the folding and function of proteins, but how it contributes
to protein misfolding and aggregation has still to be elucidated. We show that the mobility of …

Conventional in vitro aggregation assays often involve tagging with extrinsic fluorophores,
which can interfere with aggregation. We propose the use of intrinsic amyloid fluorescence …

… Chyi Wei Chung is currently a PhD student under the supervision of Dr. Gabriele Kaminski
Schierle. Her research involves using intracellular thermometry and fluorescence lifetime …

During aging, proteostasis capacity declines and distinct proteins become unstable and can
accumulate as protein aggregates inside and outside of cells. Both in disease and during …

Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to
lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and …

Sub-diffraction resolution, gentle sample illumination, and the possibility to image in multiple
colors make Structured Illumination Microscopy (SIM) an imaging technique which is …

The molecular mechanisms that connect the formation of aberrant cytoplasmic FUS condensates
to biological malfunction are incompletely understood. Here, we develop an approach …

Structured Illumination Microscopy, SIM, is one of the most powerful optical imaging methods
available to visualize biological environments at subcellular resolution. Its limitations stem …

Neurodegenerative disorders are a family of diseases that remain poorly treated despite
their growing global health burden. A shared feature of many neurodegenerative disorders is …