Background Several Cre reporter strains of mice have been described, in which a lacZ gene
is turned on in cells expressing Cre recombinase, as well as their daughter cells, following …

Complementary sets of genes are epigenetically silenced in male and female gametes in a
process termed genomic imprinting. TheDnmt3L gene is expressed during gametogenesis at …

Although the hormone erythropoietin (Epo) and its receptor (EpoR) are known to play
important roles in the regulation of erythropoiesis, several questions remain concerning the …

Many proteins have been proposed to act as surrogate markers of organ damage, yet for
many candidates the essential biomarker characteristics that link the protein to the injured …

GATA-1 is a zinc-finger transcription factor believed to play an important role in gene
regulation during the development of erythroid cells, megakaryocytes and mast cells. Other …

Erythropoietin, known for its role in erythroid differentiation, has been shown to be neuroprotective
during brain ischaemia in adult animal models. Although high levels of erythropoietin …

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve …

Developing organs require iron for a myriad of functions, but embryos deleted of the major
adult transport proteins, transferrin or its receptor transferrin receptor1 (TfR1 −/− ), still initiate …

Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial
breast and ovarian cancer. The BRCA1 protein displays E3 ubiquitin ligase activity, and this …

MACF1 (microtubule actin cross-linking factor 1) is a multidomain protein that can associate
with microfilaments and microtubules. We found that MACF1 was highly expressed in …