Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?

CZ Chen, B Neumann, S Förster… - Open …, 2021 - royalsocietypublishing.org
Myelin sheaths, by supporting axonal integrity and allowing rapid saltatory impulse
conduction, are of fundamental importance for neuronal function. In response to demyelinating …

[HTML][HTML] SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice

…, CZ Chen, M Turmaine, CY Chen… - Frontiers in Cellular …, 2023 - frontiersin.org
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition
has become an attractive therapeutic strategy to preserve axons in a variety of disorders …

A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression

…, C Zhao, A Mannioui, E Martin, A Fleet, CZ Chen… - Cell, 2024 - cell.com
Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes
in the central nervous system (CNS). This evolutionary innovation, which first appears in …

Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelination

…, B Neumann, C McClain, L Di Canio, CZ Chen… - BioRxiv, 2020 - biorxiv.org
Oligodendrocytes that generate new myelin sheaths around demyelinated axons in the
regenerative process of remyelination are generally derived from oligodendrocyte progenitor …

Investigating neuroectodermal transdifferentiation: how do CNS progenitors form Schwann cells?

C Chen - 2023 - repository.cam.ac.uk
Myelin sheaths provide trophic support to axons, allow rapid nerve impulse conduction and
are critical for neuronal function. Under homeostatic conditions, axons of the central nervous …

SARM1 detection in oligodendrocytes but not Schwann cells though sarm1/Sarm1 deletion does not perturb CNS nor PNS myelination in zebrafish and mice

…, C Mutschler, CZ Chen, M Turmaine, CY Chen… - bioRxiv, 2022 - biorxiv.org
SARM1 is a central regulator of programmed axon death and is required to initiate axon self-destruction
after traumatic and toxic insults to the nervous system. Abnormal activation of …

[PDF][PDF] Selected Research Articles

C Shih, G Wu, S Lo, H Lin, Z Chen - sigapp.org
… on propagation delay on table update was caused by the MAC control in Z-wave protocol. …
z denotes we work with a dynamic system of the first order and implies the invocation of the …

Myc determines the functional age state of oligodendrocyte progenitor cells

…, A Young, S Förster, A Sharma, CZY Chen… - Nature Aging, 2021 - nature.com
… 203151/Z/16/Z). BN was supported by a Kim and Julianna Silverman research fellowship
and a donation from the Mikheelev family trust. KSR was supported by a … Civia Zi-Yu Chen

Targeted evolution of adeno-associated virus capsids for systemic transgene delivery to microglia and tissue-resident macrophages

…, B Neumann, M Segel, CZY Chen… - Proceedings of the …, 2023 - National Acad Sciences
Tissue macrophages, including microglia, are notoriously resistant to genetic manipulation.
Here, we report the creation of Adeno-associated viruses (AAV) variants that efficiently and …

Olfactory exposure to late-pregnant and lactating mice causes stress-induced analgesia in male mice

SF Rosen, LV Lima, C Chen, R Nejade, M Zhao… - Science …, 2022 - science.org
In an attempt to improve reproducibility, more attention is being paid to potential sources of
stress in the laboratory environment. Here, we report that the mere proximity of pregnant or …