[HTML][HTML] Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

C Defois, J Ratel, G Garrait, S Denis, O Le Goff… - Scientific reports, 2018 - nature.com
Growing evidence indicates that the human gut microbiota interacts with xenobiotics, including
persistent organic pollutants and foodborne chemicals. The toxicological relevance of the …

[HTML][HTML] Environmental Pollutant Benzo[a]Pyrene Impacts the Volatile Metabolome and Transcriptome of the Human Gut Microbiota

C Defois, J Ratel, S Denis, B Batut, R Beugnot… - Frontiers in …, 2017 - frontiersin.org
Benzo[a]pyrene (B[a]P) is a ubiquitous, persistent, and carcinogenic pollutant that belongs to
the large family of polycyclic aromatic hydrocarbons. Population exposure primarily occurs …

[HTML][HTML] Capturing prokaryotic dark matter genomes

C Gasc, C Ribière, N Parisot, R Beugnot, C Defois… - Research in …, 2015 - Elsevier
Prokaryotes are the most diverse and abundant cellular life forms on Earth. Most of them,
identified by indirect molecular approaches, belong to microbial dark matter. The advent of …

[HTML][HTML] Microbial diversity under the influence of natural gas storage in a deep aquifer

…, M Guignard, F Casteran, M Abadie, C Defois… - Frontiers in …, 2021 - frontiersin.org
Deep aquifers (up to 2km deep) contain massive volumes of water harboring large and diverse
microbial communities at high pressure. Aquifers are home to microbial ecosystems that …

[HTML][HTML] Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice

A Bravard, C Gérard, C Defois, B Benoit, K Makki… - Scientific Reports, 2021 - nature.com
Although the mechanism of action of the antidiabetic drug metformin is still a matter of
discussions, it is well accepted that the gut plays an important role. To gain more insights into the …

ASaiM: a Galaxy-based framework to analyze microbiota data

B Batut, K Gravouil, C Defois, S Hiltemann… - …, 2018 - academic.oup.com
Background New generations of sequencing platforms coupled to numerous bioinformatics
tools have led to rapid technological progress in metagenomics and metatranscriptomics to …

Capture by hybridization for full‐length barcode‐based eukaryotic and prokaryotic biodiversity inventories of deep sea ecosystems

B Günther, S Marre, C Defois, T Merzi… - Molecular Ecology …, 2022 - Wiley Online Library
Biodiversity inventory of marine systems remains limited due to unbalanced access to the
three ocean dimensions. The use of environmental DNA (eDNA) for metabarcoding allows fast …

Targeted gene capture by hybridization to illuminate ecosystem functioning

…, R Beugnot, N Parisot, C Gasc, C Defois… - Microbial environmental …, 2016 - Springer
Microbial communities are extremely abundant and diverse on earth surface and play key
role in the ecosystem functioning. Thus, although next-generation sequencing (NGS) …

ASaiM: a Galaxy-based framework to analyze raw shotgun data from microbiota

B Batut, K Gravouil, C Defois, S Hiltemann, JF Brugère… - bioRxiv, 2017 - biorxiv.org
Background New generation of sequencing platforms coupled to numerous bioinformatics
tools has led to rapid technological progress in metagenomics and metatranscriptomics to …

Etude de l'impact de contaminats chimiques alimentaires sur le microbiote intestinal humain.

C Defois - 2017 - theses.hal.science
L’exposition aux polluants environnementaux a été associée à de nombreux désordres
métaboliques, immunitaires et reproductifs ainsi qu’à divers cancers. De plus en plus de travaux, …