Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like
anchor protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral immune …

Inadequate local cell-mediated immunity appears crucial for the establishment of chronic
HIV infection. Accumulation of regulatory T cells (T reg) at the site of HIV replication, the …

Background Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality and is
not uncommonly associated with chorioamnionitis. We recently have demonstrated that the …

Immaturity of the immune system has been suggested as an underlying factor for the high
rate of morbidity and mortality from infections in newborns. Functional impairment of neonatal …

A hallmark of aging is the progressive deterioration of immune function. Age-related immune
suppression increases susceptibility to infectious diseases and cancer, significant causes …

We have previously shown that regulatory T cells (Treg) accumulate dramatically in aged
animals and negatively impact the ability to control persistent infection. However, the …

Impaired functionality of dendritic cells (DCs) significantly contributes to decreased adaptive
immune responses in aged hosts. The expression of MHC-peptide on the DC surface is the …

Chorioamnionitis is a frequent cause of preterm birth and is associated with an increased
risk for injury responses in the lung, gastrointestinal tract, brain, and other fetal organs. …

We hypothesized that regulatory T cells (Tregs) could play a beneficial role during HIV infection
by controlling HIV replication in conventional T cells (Tcons). Purified Tregs and Tcons …

Regulatory T cells (Treg) are a subpopulation of CD4 + T cells characterized by the suppressive
activity they exert on effector immune responses, including human immunodeficiency …