[HTML][HTML] A Non-Coding RNA Promotes Bacterial Persistence and Decreases Virulence by Regulating a Regulator in Staphylococcus aureus

C Romilly, C Lays, A Tomasini, I Caldelari… - PLoS …, 2014 - journals.plos.org
Staphylococcus aureus produces a high number of RNAs for which the functions are poorly
understood. Several non-coding RNAs carry a C-rich sequence suggesting that they …

[HTML][HTML] Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence

…, A Martin, L Lindgren, C Punginelli, C Lays… - PLoS …, 2016 - journals.plos.org
The virulence of Francisella tularensis, the etiological agent of tularemia, relies on an atypical
type VI secretion system (T6SS) encoded by a genomic island termed the Francisella …

The effects of weathering and chemical dispersion on Deepwater Horizon crude oil toxicity to mahi-mahi (Coryphaena hippurus) early life stages

…, TL Brown, BL French, TL Linbo, C Lay… - Science of the Total …, 2016 - Elsevier
To better understand the impact of the Deepwater Horizon (DWH) incident on commercially
and ecologically important pelagic fish species, a mahi-mahi spawning program was …

A multiple endpoint analysis of the effects of chronic exposure to sediment contaminated with Deepwater Horizon oil on juvenile Southern flounder and their …

…, M Krasnec, R Takeshita, CN Ryan, KJ Griffitt, C Lay… - Aquatic Toxicology, 2015 - Elsevier
Exposure to oiled sediments can negatively impact the health of fish species. Here, we
examine the effects of chronic exposure of juvenile southern flounder, Paralichthys lethostigma, …

[HTML][HTML] The Expression of Small Regulatory RNAs in Clinical Samples Reflects the Different Life Styles of Staphylococcus aureus in Colonization vs. Infection

J Song, C Lays, F Vandenesch, Y Benito, M Bes… - PLoS …, 2012 - journals.plos.org
Small RNAs (sRNAs) are involved in the post-transcriptional regulation of metabolic
pathways and in responses to stress and virulence. We analyzed the expression levels of five …

Responses of juvenile southern flounder exposed to Deepwater Horizon oil‐contaminated sediments

…, MO Krasnec, CR Lay… - Environmental …, 2017 - Wiley Online Library
The Deepwater Horizon oil spill released millions of barrels of crude oil into the northern
Gulf of Mexico, much of which remains associated with sediments and can have continuing …

A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA

S Masachis, NJ Tourasse, C Lays, M Faucher… - Elife, 2019 - elifesciences.org
10.7554/eLife.47549.001 Post-transcriptional regulation plays important roles to fine-tune
gene expression in bacteria. In particular, regulation of type I toxin-antitoxin (TA) systems is …

[HTML][HTML] Community-facing toxicokinetic models to estimate PFAS serum levels based on life history and drinking water exposures

MT Lynch, CR Lay, S Sokolinski, A Antezana… - Environment …, 2023 - Elsevier
Background Per- and polyfluoroalkyl substances (PFAS) are drinking water contaminants.
Tools to assess the potential body burden associated with drinking PFAS-contaminated water …

[HTML][HTML] Critical role of a sheath phosphorylation site on the assembly and function of an atypical type VI secretion system

…, G Prigent, F Tros, M Barel, M Coureuil, C Lays… - Molecular & Cellular …, 2019 - ASBMB
The bacterial pathogen Francisella tularensis possesses a noncanonical type VI secretion
system (T6SS) that is required for phagosomal escape in infected macrophages. KCl …

[HTML][HTML] Using proteomics to identify host cell interaction partners for VgrG and IglJ

M Proksova, H Rehulkova, P Rehulka, C Lays… - Scientific Reports, 2020 - nature.com
Francisella tularensis is a highly virulent intracellular bacterium and the causative agent of
tularemia. The disease is characterized by the suboptimal innate immune response and …