Diabetes mellitus is a chronic disease that leads to complications including heart disease,
stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-…

The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

We have identified a family of resistin-like molecules (RELMs) in rodents and humans.
Resistin is a hormone produced by fat cells. RELMα is a secreted protein that has a restricted …

The association between obesity and diabetes supports an endocrine role for the adipocyte
in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte …

Obesity is a major risk factor for insulin resistance and type 2 diabetes mellitus. Adipocytes
secrete numerous substances that might contribute to peripheral insulin sensitivity. These …

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS
CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute …

Leptin, the product of the obese gene, is a circulating hormone secreted primarily from
adipocytes. The lack of leptin in ob/ob mice, who are homozygous for the obese gene, results in …

Obesity and noninsulin‐dependent diabetes mellitus are globally epidemic. Insulin resistance
is a major contributor to the pathogenesis of type II diabetes and plays a role in numerous …

Thiazolidinediones (TZDs) are effective therapies for type 2 diabetes, which has reached
epidemic proportions in industrialized societies. TZD treatment reduces circulating free fatty …

Resistin is an adipocyte hormone that modulates glucose homeostasis. Here we show that in
3T3-L1 adipocytes, resistin attenuates multiple effects of insulin, including insulin receptor (…