Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free
DNA, molecular heterogeneity of cancer, and sample sizes that are not sufficient to …

KLF4/GLKF4 is a transcription factor that can have divergent functions in different malignancies.
The role of KLF4 in prostate cancer etiology remains unclear. We have recently reported …

The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major
challenge for clinicians. We discovered a potential marker, the sodium-dependent glucose …

Purpose: As a transcriptional repressor of E-cadherin, Snail has predominantly been
associated with epithelial-mesenchymal transition, invasion, and metastasis. However, other …

Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs. Deciphering
the tissue origin of cfDNA can reveal abnormal cell death because of diseases, which …

Small cell neuroendocrine carcinoma (SCNC) of the prostate is a variant form of prostate
cancer that occurs de novo or as a recurrent tumor in patients who received hormonal therapy …

Purpose: Prostate-specific membrane antigen (PSMA) targeting radioligands deliver
radiation to PSMA-expressing cells. However, the relationship between PSMA levels and …

Parathyroid hormone (PTH) regulates extracellular calcium homeostasis through the type 1
PTH receptor (PTH1R) expressed in kidney and bone. The PTH1R undergoes β-arrestin/…

The chemopreventive activity of green tea (GT) is limited by the low bioavailability and
extensive methylation of GT polyphenols (GTPs) in vivo. We determined whether a methylation …

We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive
nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human …