[HTML][HTML] Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

…, JA Engel, J Straube, BS Thomas, CPS Pernold… - Nature …, 2020 - nature.com
The dynamics of CD4 + T cell memory development remain to be examined at genome scale.
In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation …

[HTML][HTML] Gene expression of peripheral blood mononuclear cells and CD8+ T cells from gilts after PRRSV infection

E Lagumdzic, CPS Pernold, R Ertl, N Palmieri… - Frontiers in …, 2023 - frontiersin.org
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-stranded RNA
virus, which emerged in Europe and USA in the late 1980s and has since caused huge …

[HTML][HTML] Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

…, BS Thomas, P Laohamonthonkul, CPS Pernold… - PLoS …, 2019 - journals.plos.org
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of
maturation, asexual replication, rupture and release of multiple infective merozoites, …

[HTML][HTML] Species comparison: human and minipig PBMC reactivity under the influence of immunomodulating compounds in vitro

CPS Pernold, E Lagumdzic, M Stadler… - Frontiers in …, 2024 - frontiersin.org
Considering the similarities between swine and humans, it is a logical consequence to use
swine as a translational model in research and drug development, including non-clinical …

[HTML][HTML] Comparative analysis of swine leukocyte antigen gene diversity in Göttingen Minipigs

…, M Gociman, S Groiss, CPS Pernold… - Frontiers in …, 2024 - frontiersin.org
Worldwide, pigs represent economically important farm animals, also representing a
preferred preclinical large animal model for biomedical studies. The need for swine leukocyte …

Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice

…, MSF Soon, BS Thomas, CPS Pernold… - International journal for …, 2018 - Elsevier
A major mechanism of host-mediated control of blood-stage Plasmodium infection is thought
to be removal of parasitized red blood cells (pRBCs) from circulation by the spleen or …

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites

…, MSF Soon, CG Williams, A SheelaNair, CPS Pernold… - Mbio, 2023 - Am Soc Microbiol
Maturation rates of malaria parasites within red blood cells (RBCs) can be influenced by
host nutrient status and circadian rhythm; whether host inflammatory responses can also …

[HTML][HTML] Characterization of the immune system of Ellegaard Göttingen Minipigs-An important large animal model in experimental medicine

CPS Pernold, E Lagumdzic, M Stadler… - Frontiers in …, 2022 - frontiersin.org
Interest in Ellegaard Göttingen Minipigs (EGMs) as a model in experimental medicine is
continuously growing. The aim of this project is to increase the knowledge of the immune system …

Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4+ T cells

…, LS Clarke, P Laohamonthonkul, CPS Pernold… - bioRxiv, 2019 - biorxiv.org
CD4 + T cells are repositories of immune memory, conferring enhanced immunity to many
infectious agents. Studies of acute viral and bacterial infection suggest that memory CD4 + T …

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem …

…, N Viceconte, C Strandgren, K Pernold… - Human molecular …, 2015 - academic.oup.com
Hutchinson–Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with
multiple features suggestive of premature accelerated aging. Accumulation of progerin is …