The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging.
Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to …

The molecular mechanisms regulating the sexual development of malaria parasites from
gametocytes to oocysts in their mosquito vector are still largely unexplored. In other eukaryotes, …

The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its
amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; …

Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent
while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes …

The molecular control of cell division and development in malaria parasites is far from
understood. We previously showed that a Plasmodium gametocyte-specific NIMA-related protein …

Sequence diversity in pathogen antigens is an obstacle to the development of interventions
against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 …

Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity
and mortality impact in the developing world. The propensity of the parasites to develop …

Background Post-transcriptional control of gene expression is suspected to play an important
role in malaria parasites. In yeast and metazoans, part of the stress response is mediated …

Blood group O is associated with protection against severe malaria and reduced size and
stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood groups. …

Malaria remains a devastating disease with respect to both mortality and the constraints it
places on the economic development of the countries in which it is endemic. Our laboratory is …