Adaptation is fundamental to life. All organisms adapt over timescales that span from evolution
to generations and lifetimes to moment-by-moment interactions. The nervous system is …

10.7554/eLife.07192.001 Optogenetic techniques enable precise excitation and inhibition of
firing in specified neuronal populations and artifact-free recording of firing activity. Several …

It has been posited that the regulation of burst/tonic firing in the thalamus could function as a
mechanism for controlling not only how much but what kind of information is conveyed to …

Objective. Controlling neural activity enables the possibility of manipulating sensory perception,
cognitive processes, and body movement, in addition to providing a powerful framework …

Reproducible research and open science practices have the potential to accelerate scientific
progress by allowing others to reuse research outputs, and by promoting rigorous research …

The thalamus acts as an interface between the periphery and the cortex, with nearly every
sensory modality processing information in the thalamocortical circuit. Despite well-…

As the tools to simultaneously record electrophysiological signals from large numbers of
neurons within and across brain regions become increasingly available, this opens up for the …

In the thermal system, skin cooling is represented in the primary somatosensory cortex (S1)
and the posterior insular cortex (pIC). Whether S1 and pIC are nodes in anatomically …

Rodents use active whisker movements to explore their environment. The “slip hypothesis”
of whisker-related tactile perception entails that short-lived kinematic events (abrupt whisker …

Artificial activation of neural circuitry through electrical microstimulation and optogenetic
techniques is important for both scientific discovery of circuit function and for engineered …